“…Possible explanations for this finding include inflammatory cell recruitment to the genital tract and epithelial damage resulting from the local toxicity of nonoxynol-9 [20,21]. Secondly, it is crucial that a microbicide is used correctly, so it must be easy to use, acceptable to the user, should not interfere with sexual intercourse, and should have an appropriate duration of action [22]. Thirdly, a microbicide should be stable at the high temperatures typically encountered in developing countries, because refrigerated storage is not feasible in those regions most in need of these products.…”