Microbial volatile organic compounds in the air of moldy and mold-free indoor environments

Schleibinger, Hans; Laußmann, Detlef; Bornehag, Carl‐Gustaf; Eis, Dieter; Rueden, H.

doi:10.1111/j.1600-0668.2007.00513.x

Cited by 89 publications

(49 citation statements)

References 42 publications

(45 reference statements)

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“…In the previous study, 1-octen-3-ol associated with inspected mold status; however, in only a small portion (Schleibinger et al, 2008) and there must be other sources such as hidden mold growth due to condensation on walls (Small, 2003).…”

Section: Discussionmentioning

confidence: 76%

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Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Araki

Kawai

Eitaki

et al. 2010

Science of The Total Environment

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Abstract:Micro-organisms are known to produce a range of volatile organic compounds, so-called microbial VOC (MVOC). Chamber studies where humans were exposed to MVOC addressed the acute effects of objective and/or subjective signs of mucosal irritation. However, the effect of MVOC on inhabitants due to household exposure is still unclear. The purpose of this epidemiological study was to measure indoor MVOC levels in single family homes and to evaluate the relationship between exposure to them and sick building syndrome (SBS). All inhabitants of the dwellings were given a self-administered questionnaire with standardized questions to assess their symptoms.Air samples were collected and the concentrations of eight selected compounds in indoor air were analyzed by gas chromatography/mass spectrometry -selective ion monitoring mode (GC/MS-SIM). The most frequently detected MVOC was 1-pentanol at a detection rate of 78.6% and geometric mean of 0.60 μg/m 3 . Among 620 participants, 120 (19.4%) reported one or more mucous symptoms; irritation of the eyes, nose, airway, or coughing every week (weekly symptoms), and 30 (4.8%) reported that the symptoms were home-related (home-related symptoms). Weekly symptoms were not associated with any of MVOC, whereas significant associations between home-related mucous symptoms and 1-octen-3-ol (per log 10 -unit: odds ratio (OR) 5.6, 95% confidence interval (CI): 2.1 to 14.8) and 2-pentanol (per log 10 -unit: OR 2.3, 95%CI: 1.0 to 4.9) were obtained after adjustment for gender, age, and smoking.Associations between home-related symptoms and 1-octen-3-ol remained after mutual adjustment. However, concentrations of the selected compounds in indoors were lower than the estimated safety level in animal studies. Thus, the statistically significant association between 1-octen-3-ol may be due to a direct effect of the compounds or the associations may be being associated with other offending compounds. Additional studies are needed to evaluate these possibilities.

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Section: Discussionmentioning

confidence: 76%

“…However, compounds, so-called MVOC, are also emitted from plants, furniture, furnishing, and building materials (Konig et al, 1995;Korpi et al, 1999;Pasanen et al, 1998;Schleibinger et al, 2004). Previous studies failed to find any strong association between indoor mold status and MVOC (Schleibinger et al, 2005;Schleibinger et al, 2008).…”

Section: Introductionmentioning

confidence: 71%

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Araki

Kawai

Eitaki

et al. 2010

Science of The Total Environment

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“…The exact concentration of any given fungal VOC in water-damaged, moldy buildings is difficult to measure because concentrations vary depending on the ventilation rate, moisture, temperature, and other parameters. However, reported concentrations of 1-octen-3-ol in moldy buildings and classrooms range from 0.2 μg/m 3 (0.00004 ppm) up to 900 μg/m 3 (0.16 ppm) (15,(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Inamdar

Hossain

Bernstein

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Parkinson disease (PD) is the most common movement disorder and, although the exact causes are unknown, recent epidemiological and experimental studies indicate that several environmental agents may be significant risk factors. To date, these suspected environmental risk factors have been man-made chemicals. In this report, we demonstrate via genetic, biochemical, and immunological studies that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine levels and causes dopamine neuron degeneration in Drosophila melanogaster. Overexpression of the vesicular monoamine transporter (VMAT) rescued the dopamine toxicity and neurodegeneration, whereas mutations decreasing VMAT and tyrosine hydroxylase exacerbated toxicity. Furthermore, 1-octen-3-ol also inhibited uptake of dopamine in human cell lines expressing the human plasma membrane dopamine transporter (DAT) and human VMAT ortholog, VMAT2. These data demonstrate that 1-octen-3-ol exerts toxicity via disruption of dopamine homeostasis and may represent a naturally occurring environmental agent involved in parkinsonism.building-related illness | mold | mushroom alcohol

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“…Many published studies have confirmed the presence of fungal contamination in indoor environments and it has been reported that fungal spores and microbial volatile organic compounds (MVOCs) emitted from fungi have adverse health effects [1][2][3][4][5][6][7][8]. Fungal growth in indoor environments is strongly related to the indoor physical and chemical conditions, such as atmospheric air temperature, relative humidity, hydrogen-ion exponent (pH) in free water and nutrients; therefore, a comprehensive prediction method must be developed to estimate fungal growth and the subsequent health risk of fungal contamination for exposed individuals.…”

Section: Introductionmentioning

confidence: 99%

Numerical Prediction Model for Fungal Growth Coupled with Hygrothermal Transfer in Building Materials

Ito

2011

Indoor and Built Environment

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A mathematical model that reproduces fungal proliferation and morphological colony formation was developed on the basis of a reaction diffusion modelling approach. In this modelling, fungal life stage was separated into two, active and inactive stage, and it was assumed that active fungus moves by diffusion and reaction while generating and producing inactive fungus. The effects of temperature and humidity on fungal growth were explicitly incorporated in the reaction term of nutrient consumption/production of active fungus in this governing equation. The damping function, which reproduces the effects of temperature and humidity on fungal growth, was developed and explicitly based on the fungal index proposed by K. Abe. In order to estimate the sensitivity of the proposed numerical fungal growth model, fungal growth on the surface of building materials was analysed for four types of building materials, and the prediction results were compared with the results of WUFI-Bio and the fungal index.

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Microbial volatile organic compounds in the air of moldy and mold-free indoor environments

Cited by 89 publications

References 42 publications

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Numerical Prediction Model for Fungal Growth Coupled with Hygrothermal Transfer in Building Materials

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