Microbial Triggers in Autoimmunity, Severe Allergy, and Autoallergy

Badloe, Fariza; Janmohamed, Sherief R.; Ring, Johannes; Gutermuth, Jan

doi:10.1007/978-3-319-69968-4_2

Cited by 1 publication

(1 citation statement)

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“…The origin of autoimmune disease (AD) in humans have previously been thought of as triggered by microbial infection, which may serve as a catalyst for development of responses to self-antigens [reviewed in (218)]. Several autoimmune diseases are associated with bacterial triggers, such as gastric autoimmunity and Guillain-Barré syndrome triggered by infection with H. pylori and C. jejuni, respectively [reviewed in (219)]. One proposed mechanism for possible LD-associated autoimmunity is the circumstance where sequence or structural homology between human and Bb proteins cause B-and T-cell receptors to cross-react with an epitope on a Bb protein (the intended target) and a human protein (the unintended target).…”

Section: Autoantigens and Self-reactivity In La Patientsmentioning

confidence: 99%

Recent Progress in Lyme Disease and Remaining Challenges

Bobe

Jutras

Horn³

et al. 2021

Front. Med.

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Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.

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Section: Autoantigens and Self-reactivity In La Patientsmentioning

confidence: 99%