Microbial treatment in chronic constipation

Abstract

Chronic functional constipation is a kind of common intestinal disease that occurs in children, adults and elderly people. This disease not only causes great influence to physiological function, but also results in varying degrees of psychological barriers. At present, constipation treatments continue to rely on traditional methods such as purgative therapy and surgery. However, these approaches can disrupt intestinal function. Recent research between intestinal diseases and gut microbiota has gradually revealed a connection between constipation and intestinal flora disturbance, providing a theoretical basis for microbial treatment in chronic constipation. Microbial treatment mainly includes probiotic preparations such as probiotics, prebiotics, synbiotics and fecal microbiota transplantation (FMT). Due to its safety, convenience and curative effect, probiotic preparations have been widely accepted, especially gradually developed FMT with higher curative effects. Microbial treatment improves clinical symptoms, promotes the recovery of intestinal flora, and has no complications during the treatment process. Compared with traditional treatments, microbial treatment in chronic constipation has advantages, and is worthy of further promotion from clinical research to clinical application.

Case-Control Study of the Effects of Gut Microbiota Composition on Neurotransmitter Metabolic Pathways in Children With Attention Deficit Hyperactivity Disorder

“…At the species level, F. prausnitzii, L. bacterium, and R. gnavus were significantly reduced in the ADHD group, while B. caccae, O. splanchnicus, P. xylaniphila, and V. parvula were significantly increased. Additionally, we found that children with ADHD were more prone to constipation; consistent with our finding, previous studies have reported that the imbalance of intestinal flora is closely related to the occurrence of constipation (Huang et al, 2018;Wen et al, 2018;.…”

Microbiome: from community metabolism to host diseases

“…The safety, convenience and curative effect of microbial treatment including probiotic preparations (i.e. probiotics, prebiotics, synbiotics) and fecal microbiota transplantation (FMT) were discussed thoroughly (Huang et al, 2018). Interestingly, Zhang et al also report the long-term effect of FMT combined with soluble dietary fiber (pectin) in treating slow transit constipation (STC).…”

Lactobacillus reuteri DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial

“…A synbiotic is a mixture of probiotics and prebiotics that beneficially affects the host [ 12 ]. Targeting treatments for dysbiosis with probiotics, prebiotics, and synbiotics improve clinical symptoms, promote the recovery of intestinal flora, and may be a new option that is significantly useful for the treatment of chronic constipation [ 13 , 14 ]. It has been reported in children and adults with functional constipation, treatment with L. reuteri DSM 17938 improves defecating frequency [ 8 , 15 , 16 ].…”