2007
DOI: 10.1016/j.bmcl.2007.09.065
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Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure–activity relationship (SAR)

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Cited by 36 publications
(11 citation statements)
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“…After analyzing and comparing these data online (SciFinder Scholar) with reported compounds and references, the structures of Compounds 1 and 2 were identified as resibufogenin (Compound 1) and cinobufagin (Compound 2) (Fig. 1), which were previously detected in the parotid secretions of the toads B. marinus, B. gargarizans and B. melanostictus (15,16).…”
Section: Identification Of the Active Compounds Compound 1 Was Obtaimentioning
confidence: 99%
“…After analyzing and comparing these data online (SciFinder Scholar) with reported compounds and references, the structures of Compounds 1 and 2 were identified as resibufogenin (Compound 1) and cinobufagin (Compound 2) (Fig. 1), which were previously detected in the parotid secretions of the toads B. marinus, B. gargarizans and B. melanostictus (15,16).…”
Section: Identification Of the Active Compounds Compound 1 Was Obtaimentioning
confidence: 99%
“…[12] Bufadienolides, such as, bufotalin, bufalin, cinobufagin, and resibufogenin, have been reported as Na + -K + -ATPase inhibitors and exhibit cytotoxic and growth-inhibitory activity against various human cancer cells in vitro . [1314]…”
Section: Introductionmentioning
confidence: 99%
“…Much recent research on bufadienolides has focused on isolation and purification, structure determination, quantitative analysis, and investigation of microbial transformation and quality control 16–20. However, to our knowledge, few studies have been published on the structural characterization of bufadienolides by LC/MS.…”
mentioning
confidence: 99%