Microbial transformation of sesquitepenoid ketone, (+) Nootkatone by &lt;i&gt;Macrophomia phaseolina&lt;/i&gt;

Bulugahapitiya, Vajira P.; Musharaff, S. G.

doi:10.4038/rjs.v4i0.56

Cited by 4 publications

(3 citation statements)

References 13 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(+)-Nootkatone was transformed also by the plant pathogenic fungus Macrophomia phaseolina, giving rise to four main compounds, two of them in stereoisomeric mixture. The substrate and two other products, 13-hydroxynootkatone and 12-hydroxy-11,12-dihydroxynootkatone, revealed significant antiprotozoal activity [109].…”

Section: Substrate Additionmentioning

confidence: 94%

Microbial Transformations of Plant Secondary Metabolites

Mutafova¹,

Fernandes²,

Mutafov³

et al. 2016

Bioprocessing of Plant in Vitro Systems

View full text Add to dashboard Cite

The aim of this chapter is to present the authors' view on the place and role of microbial transformation reactions as a perspective means of processing of plantderived biologically active compounds into metabolites with new and/or increased activity and availability and decreased toxicity. Some microbial transformations providing information regarding metabolism in humans and mammals of plant-derived secondary metabolites applied as drugs and/or food additives are also considered.

show abstract

Section: Substrate Additionmentioning

confidence: 94%

Microbial Transformations of Plant Secondary Metabolites

Mutafova¹,

Fernandes²,

Mutafov³

et al. 2016

Bioprocessing of Plant in Vitro Systems

View full text Add to dashboard Cite

show abstract

“…Phytochemical tests for flavonoids, saponins, lactones, phenolic hydroxyls, unsaturation, coumarins, alkaloids, sesquiterpene lactones, steroids, terpenes, carbonyl groups, sugars, and anthocyanins were performed on both plant material and C. citratus EO using previously reported methodologies [ 23 , 24 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

Cymbopogon citratus Essential Oil: Extraction, GC–MS, Phytochemical Analysis, Antioxidant Activity, and In Silico Molecular Docking for Protein Targets Related to CNS

Cortes-Torres,

López-Castillo,

Marín-Torres

et al. 2023

CIMB

View full text Add to dashboard Cite

This study analyzed the chemical composition of Cymbopogon citratus essential oil from Puebla, México, assessed its antioxidant activity, and evaluated in silico protein–compound interactions related to central nervous system (CNS) physiology. GC–MS analysis identified myrcene (8.76%), Z-geranial (27.58%), and E-geranial (38.62%) as the main components, with 45 other compounds present, which depends on the region and growing conditions. DPPH and Folin–Ciocalteu assays using the leaves extract show a promising antioxidant effect (EC50 = 48.5 µL EO/mL), reducing reactive oxygen species. The bioinformatic tool SwissTargetPrediction (STP) shows 10 proteins as potential targets associated with CNS physiology. Moreover, protein–protein interaction diagrams suggest that muscarinic and dopamine receptors are related to each other through a third party. Molecular docking reveals that Z-geranial has higher binding energy than M1 commercial blocker and blocks M2, but not M4 muscarinic acetylcholine receptors, whereas β-pinene and myrcene block M1, M2, and M4 receptors. These actions may positively affect cardiovascular activity, memory, Alzheimer’s disease, and schizophrenia. This study highlights the significance of understanding natural product interactions with physiological systems to uncover potential therapeutic agents and advanced knowledge on their benefits for human health.

show abstract

“…Ethyl-acetate extracted a wider range of Source: Ramavhale, T.T., 2024, 'Isolation, structure elucidation, antimicrobial activity, and effects of plant extracts used for the treatment of "u wela"', PhD thesis, University of Limpopo compounds of polar alkaloids, non-polar lipids, as well as essential oils. Acetone isolates non-polar fats, oils, and specific non-polar secondary metabolites (Bulugahapitiya 2013). Other researchers found that acetone can dissolve both polar and non-polar compounds (Maulidiyah et al 2023).…”

Section: Extraction Of Plant Materials Using Different Solventsmentioning

confidence: 99%

Biological activity of folkloric plants used in the treatment of ‘u wela’ against pathogens

Ramavhale,

Mahlo,

Eloff

2024

Journal of Medicinal Plants for Economic Development

View full text Add to dashboard Cite

Background: ‘U wela’ also known as ‘Divhu’ in ‘Tshivenda’ is a sexually transmitted infection caused by a combination of fungal and bacterial microorganisms that affects males because of unprotected sexual encounters with a woman who has had an abortion or miscarriage.Aim: The study aimed to investigate medicinal plants used to treat ‘u wela’ and determine their biological activity against Neisseria gonorrhoeae and Candida albicans.Setting: Eight plant species (Elaeodendron transvaalense[Burtt Davy] R.H. Archer, Albizia versicolor Welw. ex Oliv, Xanthocercis zambesiaca Baker, Cassia abbreviata subsp. beareana [Holmes] Brenan, Anthocleista grandiflora Gilg, Myrothamnus flabellifolius Welw., Mimusops zeyheri Sond, and Capparis tomentosa Lam.) used to combat ‘u wela’ were selected from the Ethnomedicinal plant’s database of over 300 medicinal plants used for medicinal purposes in humans, in the Vhembe district, Limpopo province, South Africa.Methods: The antimicrobial activity of the plant extracts was investigated against Candida albicans and Neisseria gonorrhoeae using serial dilution and bioautography assays.Results: The plant extracts of A. versicolor and C. abbreviata had excellent activity with a low minimum inhibitory concentration (MIC). value of 0.02 and 0.07 mg/mL, respectively. In bioautograms developed in benzene/ethanol/ammonia hydroxide (BEA), active compounds were visible in the extracts of A. versicolor.Conclusion: A. versicolor had excellent antimicrobial activity and may be used in traditional therapy to combat ‘u wela’.Contribution: The study has demonstrated that A. versicolor is a promising plant species that could lead to the discovery of novel drugs to combat ‘u wela’.

show abstract

Microbial transformation of sesquitepenoid ketone, (+) Nootkatone by <i>Macrophomia phaseolina</i>

Cited by 4 publications

References 13 publications

Microbial Transformations of Plant Secondary Metabolites

Microbial Transformations of Plant Secondary Metabolites

Cymbopogon citratus Essential Oil: Extraction, GC–MS, Phytochemical Analysis, Antioxidant Activity, and In Silico Molecular Docking for Protein Targets Related to CNS

Biological activity of folkloric plants used in the treatment of ‘u wela’ against pathogens

Contact Info

Product

Resources

About