Microbial Transformation of Sclareol

Structure Elucidation and Antibacterial Activity of New Fungal Metabolites of Sclareol

“…3 (2006) 57 (18) group, as in 4, while the splitting pattern of the signal at d(H) 3.55 indicated hydroxylation either at C(2) or C(11). The decoupled 13 C-NMR (DEPT) spectrum of 5 ( Table 2) (Fig.…”

“…The HMBC spectrum showed heteronuclear interactions between HÀC(6) and C(8) and C(10) at d(C) 74.9 and 40.8, respectively, and between CH 2 (18) and C(19), C(4), and C(5) at d(C) 17.1, 38.5, and 49.7. This further supported OH groups at C(6) and C (18). The configuration at the newly created stereogenic center (C(6)) was deduced by a NOESY experiment (Fig.…”

Two new penterpenoid saponins and a new diterpenoid glycoside from Hemsleya chinensis

“…13 C NMR and DEPT spectra exhibited aglycone moiety in compound 3 possessed twenty carbons included three methyls, nine methylenes, three methines, and five quaternary carbons. These data indicated compound 3 was a diterpenoid-type compound (Du et al, 2001;Hieda et al, 1982a). The chemical shifts at d C 175.9 (s, C-18) indicated that 3 was a diterpenoid saponin with ester bond.…”

“…The chemical shifts at d C 175.9 (s, C-18) indicated that 3 was a diterpenoid saponin with ester bond. Comparison of the NMR data of 3 with the known compound 13b-hydroxylabda-8(17), 14-dien-18-oic acid (Du et al, 2001;Hieda et al, 1983Hieda et al, , 1982bWang et al, 2012) indicated that there was a trisaccharide moiety in 3. The deduction was confirmed by the HMBC correlations between anomeric proton at d H 5.46 (1H, s, H-1 0 ) of Rha-1 unit to carboxyl carbon at d C 175.9 (s, C-18) of aglycone unit; between anomeric proton at d H 6.25 (1H, d, J = 8.1 Hz, H-1 00 ) of Glc unit and carbon at d C 73.6 (d, C-4 0 ) of Rha-1 unit; between anomeric proton at d H 6.47 (1H, s, H-1 000 ) of Rha-2 unit and carbon at d C 76.4 (d, C-2 00 ) of Glc unit were observed.…”

A New Pathway in the Microbial Transformation ofcis-Abienol byNocardia restrietaJTS-162

“…However, this strain did not accumulate C-l7 oxidation products such as compound VI from cis-abienol even if the metabolic inhibitors were added to the culture broth. 3 ) It may be possible that this strain has pathway B or a part of pathway B for labdane transformation.…”