Microbial Trans formation of Clarias gariepinus Oil by Psuedomonas aeruginosa

Omar, Muhammad Nor; Shaban, Norhayati; Bakar, Latifah Munirah; Zuberdi, Ahmad Muzammil

doi:10.13005/ojc/300327

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2016

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“…This transformation process can be used as an alternative to chemical synthesis for the preparation of pharmacologically active compounds [1][2][3][4] . Biotransformation using Aspergillus niger has been used to transform asiaticoside to produce a product with excellent wound healing properties 5 .…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity Activity of Biotransformed Ethyl p-methoxycinnamate by Aspergillus niger

Omar¹,

Hasali²,

Yarmo³

2016

Orient. J. Chem

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The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EPHC). The biological anticancer activity of EPMC and its biotransformed product (EPHC) was established by cytotoxicity activity on the human breast cancer (MCF-7) cell line using MTT assay. Ethyl p-hydroxycinnamate (EPHC) was most cytotoxic against MCF-7 at 1000 µg/mL where percentage of cell viability was 9.87 %, while IC 50 was 340 µg/mL. EPHC showed slightly higher cytotoxicity activity compared to EPMC. The results of this study show that the biotransformation process was able to produce a metabolite (EPHC) with higher cytotoxicity activity compared to its parent compound (EPMC).

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Section: Introductionmentioning

confidence: 99%