Microbial sampling process can change results of microbiological analysis in periodontitis diagnosis. A minireview

Nguyen-Hieu, Tung

doi:10.1111/jicd.12010

Cited by 4 publications

(3 citation statements)

References 65 publications

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“…Given the small space, applying precise sampling methods is a challenge. Depending on the sampling method, different clades of microorganisms from the “same site” can be identified because of inadvertent sampling of proximal ecological communities [92]. Given the anatomy, the crude sampling tools for the periodontal pocket such as curettes and paper points yielded similar results.…”

Section: Periodontal Microbiome and Immunitymentioning

confidence: 99%

The oral microbiome and the immunobiology of periodontal disease and caries

2014

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The composition of the oral microbiome differs from one intraoral site to another, reflecting in part the host response and immune capacity at each site. By focusing on two major oral infections, periodontal disease and caries, new principles of disease emerge. Periodontal disease affects the soft tissues and bone that support the teeth. Caries is a unique infection of the dental hard tissues. The initiation of both diseases is marked by an increase in the complexity of the microbiome. In periodontitis, pathobionts and keystone pathogens such as Porphyromonas gingivalis appear in greater proportion than in health. As a keystone pathogen, P. gingivalis impairs host immune responses and appears necessary but not sufficient to cause periodontitis. Historically, dental caries had been causally linked to Streptococcus mutans. Contemporary microbiome studies now indicate that singular pathogens are not obvious in either caries or periodontitis. Both diseases appear to result from a perturbation among relatively minor constituents in local microbial communities resulting in dysbiosis. Emergent consortia of the minor members of the respective microbiomes act synergistically to stress the ability of the host to respond and protect. In periodontal disease, host protection first occurs at the level of innate gingival epithelial immunity. Secretory IgA antibody and other salivary antimicrobial systems also act against periodontopathic and cariogenic consortia. When the gingival immune response is impaired, periodontal tissue pathology results when matrix metalloproteinases are released from neutrophils and T cells mediate alveolar bone loss. In caries, several species are acidogenic and aciduric and appear to work synergistically to promote demineralization of the enamel and dentin. Whereas technically possible, particularly for caries, vaccines are unlikely to be commercialized in the near future because of the low morbidity of caries and periodontitis.

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Section: Periodontal Microbiome and Immunitymentioning

confidence: 99%

The oral microbiome and the immunobiology of periodontal disease and caries

2014

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“…Therefore sampling by the means of sterile Gracey curetes seems to be a much better sampling alternative. In the current study we measured the subgingival counts of P. intermedia and P. gingivalis by the means of qPCR in pregnant women with periodontitis comparative to non-pregnant women and men [14,15].…”

Section: Introductionmentioning

confidence: 99%

Increased Detection Rate of Prevotella Intermedia among Pregnant Periodontitis Patients in Romania

Dorneanu¹

2018

BJSTR

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Associated to pregnancy hormonal variations in plasma are favorable conditions to developing or exacerbating preexistent periodontitis. Pregnancy associated periodontal inflammation is correlated with or correlates with increasing abundance of Prevotella intermedia in the periodontal pocket. In the present study we quantified by qPCR the subgingival counts of total bacteria, P. intermedia and Porphyromonas gingivalis in pregnant women, non-pregnant and male comparatively to assess the distribution patterns of P. intermedia in periodontitis patients according to the pregnancy status of the host. P. intermedia is detected more frequently and in greater abundance in pregnant periodontitis patients.

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“…The first two articles are comprehensive reviews on osseo‐integrated implants and the use of light‐curing units in orthodontics, while the third, a meta‐analysis by Nguyen‐Hieu, describes the critical impact of microbial sampling process in the outcome of diagnostic periodontitis . Saliva is a crucial component of the oral milieu, and the works of Lima et al .…”

mentioning

confidence: 99%

New challenges in dental and oral health care

Samaranayake¹

2013

J of Invest & Clin Dent

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Microbial sampling process can change results of microbiological analysis in periodontitis diagnosis. A minireview

Cited by 4 publications

References 65 publications

The oral microbiome and the immunobiology of periodontal disease and caries

The oral microbiome and the immunobiology of periodontal disease and caries

Increased Detection Rate of Prevotella Intermedia among Pregnant Periodontitis Patients in Romania

New challenges in dental and oral health care

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