Microbial resistance related to antibiotic-loaded bone cement: a historical review

Walker, Lucy; Baker, Paul; Holleyman, Richard; Deehan, David J.

doi:10.1007/s00167-016-4309-5

Cited by 22 publications

(15 citation statements)

References 44 publications

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“…Second, we excluded patients who were treated with antibiotics other than anti-MRSA drugs or aminoglycosides, which are the most common antibiotics used with bone cement. 24 Diagnosis of periprosthetic joint infection remains challenging, even though a wide variety of tests and combinations of tests are used for diagnosis. Nevertheless, the database used in this study did not include information, such as the results of serum markers or culture of periprosthetic fluid.…”

Section: Discussionmentioning

confidence: 99%

Infection articulaire périprothétique soupçonnée après arthroplastie totale de genou sous anesthésie par propofol comparée au sévoflurane: une étude de cohorte rétrospective

Kishimoto

Yamana

Inoue

et al. 2018

Can J Anesth/J Can Anesth

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Section: Discussionmentioning

confidence: 99%

Infection articulaire périprothétique soupçonnée après arthroplastie totale de genou sous anesthésie par propofol comparée au sévoflurane: une étude de cohorte rétrospective

Kishimoto

Yamana

Inoue

et al. 2018

Can J Anesth/J Can Anesth

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“…ALBC has been widely used for the treatment of infected arthroplasty, and given the increased incidence of this type of infection, a large number of review papers is found in which aspects such as release mechanisms, clinical efficacy, and safety of the ALBC are discussed [13,118,[129][130][131][132][133].…”

Section: Antimicrobial Properties In Acrylic Bone Cementsmentioning

confidence: 99%

The Role of Chitosan and Graphene Oxide in Bioactive and Antibacterial Properties of Acrylic Bone Cements

2020

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Acrylic bone cements (ABC) are widely used in orthopedics for joint fixation, antibiotic release, and bone defect filling, among others. However, most commercially available ABCs exhibit a lack of bioactivity and are susceptible to infection after implantation. These disadvantages generate long-term loosening of the prosthesis, high morbidity, and prolonged and expensive treatments. Due to the great importance of acrylic bone cements in orthopedics, the scientific community has advanced several efforts to develop bioactive ABCs with antibacterial activity through several strategies, including the use of biodegradable materials such as chitosan (CS) and nanostructures such as graphene oxide (GO), with promising results. This paper reviews several studies reporting advantages in bioactivity and antibacterial properties after incorporating CS and GO in bone cements. Detailed information on the possible mechanisms by which these fillers confer bioactive and antibacterial properties to cements, resulting in formulations with great potential for use in orthopedics, are also a focus in the manuscript. To the best of our knowledge, this is the first systematic review that presents the improvement in biological properties with CS and GO addition in cements that we believe will contribute to the biomedical field.

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“…PMMA is incompatible with temperature-sensitive antimicrobials due to heat released during polymerization and requires explantation [7]. Unless removed in a timely manner, antimicrobials are eluted at subtherapeutic dosages that may promote antimicrobial resistance [10]. CaSO 4 is a resorbable biomaterial that eliminates the need for removal surgeries.…”

Section: Introductionmentioning

confidence: 99%

Characterization of trimethyl chitosan/polyethylene glycol derivatized chitosan blend as an injectable and degradable antimicrobial delivery system

Boles

Bumgardner

Fujiwara

et al. 2019

International Journal of Biological Macromolecules

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Advanced local delivery systems are needed as adjunctive treatments for severe injuries with high infection rates, such as open fractures. Chitosan systems have been investigated as antimicrobial local delivery systems for orthopaedic infection but possess mismatches between elution and degradation properties. Derivatives of chitosan were chosen that have enhanced swelling ratios or tailorable degradation properties. A combination of trimethyl chitosan and poly(ethylene glycol) diacrylate chitosan was developed as an injectable local delivery system. Research objectives were elution of antimicrobials for 7 days, degradation as open fractures heal, and cytocompatibility. The derivative combination eluted increased active concentrations of vancomycin and amikacin compared to the non-derivatized chitosan paste, 6 vs. 5 days and 5 vs4 days, respectively. The derivative combination degraded slower than non-derivatized paste in an enzymatic degradation study, 14 vs. 3 days, which increased antimicrobial delivery duration. Cytocompatibility of the combination with fibroblast and pre-osteoblast cells exceed the cell viability standard set in ISO 10993-5. Combination paste requires an increased ejection force of 9.40N (vs. 0.64N), but this force was within an acceptable injection force threshold, 80N. These preliminary results indicate combination paste should be further developed into a clinically useful adjunctive local delivery system for infection prevention.

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Microbial resistance related to antibiotic-loaded bone cement: a historical review

Cited by 22 publications

References 44 publications

Infection articulaire périprothétique soupçonnée après arthroplastie totale de genou sous anesthésie par propofol comparée au sévoflurane: une étude de cohorte rétrospective

Infection articulaire périprothétique soupçonnée après arthroplastie totale de genou sous anesthésie par propofol comparée au sévoflurane: une étude de cohorte rétrospective

The Role of Chitosan and Graphene Oxide in Bioactive and Antibacterial Properties of Acrylic Bone Cements

Characterization of trimethyl chitosan/polyethylene glycol derivatized chitosan blend as an injectable and degradable antimicrobial delivery system

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