Microbial recognition of human cell surface glycoconjugates

Imberty, Anne; Varrot, A.

doi:10.1016/j.sbi.2008.08.001

Cited by 259 publications

(202 citation statements)

References 53 publications

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“…It is possible that the B antigen exerts a small influence on the adherence of T. gondii to the gastrointestinal mucosa and its contribution is obscured by the high prevalence of infection by these parasites in the Brazilian population, as well as by the molecular variability of its strains identified in Brazilian patients (35)(36)(37)(38). Moreover, the use of only female patients in this study and in the one performed in France might not be sufficient to reveal possible influences of gender in the association of the ABO blood group system with infection by T. gondii (10).…”

Section: Discussionmentioning

confidence: 99%

“…This proposition is attractive, since it was demonstrated that in vitro some microorganisms bind to blood carbohydrates including those belonging to the ABO blood group system (38)(39)(40)(41). In this previous study, we included the analysis of the G428A mutation of the FUT2 gene which controls the expression of ABO blood group antigens in the GIT and defines the secretor and non-secretor phenotypes.…”

Section: Discussionmentioning

confidence: 99%

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Non-association between anti-Toxoplasma gondii antibodies and ABO blood group system

Rodrigues

Uezato

Vono

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis

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Toxoplasma gondii infects humans through the gastrointestinal tract (GIT), which elicits humoral immune response with specific antibodies. The expression of the ABO blood group glycoconjugates also occurs in this same system and may influence the human susceptibility of infection by T. gondii. The aim of the present study was to investigate the association between ABO blood group phenotypes and the presence of anti-T. gondii antibodies. Data -including age, results of serology tests for T. gondii infection and ABO blood group phenotypes -were assembled from the medical records of 1,006 pregnant women attended in the Base Hospital of the Medical School of São José do Rio Preto, Brazil, between 2001 and 2004. The chi-square test was used to compare the results with the level of significance set at 5%. Of the studied cases, 64.1% (645/1006) and 35.9% (391/1006) presented respectively positive and negative serology tests for anti-T. gondii antibodies. The mean age of those who tested positive was higher than those with negative serology tests (p = 0.0004). The frequencies of ABO blood group phenotypes were similar in those with and without anti-T. gondii antibodies (p = 0.35). In conclusion, the ABO blood group system is not associated with the presence or absence of anti-T. gondii antibodies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Non-association between anti-Toxoplasma gondii antibodies and ABO blood group system

Rodrigues

Uezato

Vono

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Together with the pattern recognition receptor Toll-like receptor (TLR) 5, MUC1 binds to bacterial flagellin, and both receptor-ligand interactions are coupled to downstream signaling (10 -12). In addition to MUC1, airway epithelia also express other sialylated surface molecules that serve as recognition motifs for pathogenic viruses and bacteria and their toxins (13). In fact, a conserved virulence factor for many respiratory pathogens is the expression of neuraminidase (14).…”

Section: Epithelial Cells (Ecs)mentioning

confidence: 99%

NEU1 Sialidase Expressed in Human Airway Epithelia Regulates Epidermal Growth Factor Receptor (EGFR) and MUC1 Protein Signaling

Lillehoj

Hyun

Feng

et al. 2012

Journal of Biological Chemistry

159

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Background: Airway epithelia express sialoglycoproteins that respond to danger signals and initiate repair programs. Results: NEU1 sialidase desialylates EGFR and MUC1 in airway epithelia to regulate their responsiveness to ligands and adhesiveness to P. aeruginosa. Conclusion: NEU1 provides an additional level of regulation over airway epithelial responsiveness to ligands and pathogens. Significance: The downstream effects of EGFR desialylation require further investigation.

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“…Pathogens frequently present surface carbohydrate-binding proteins that mediate recognition of and attachment to host cells (20). Thus, we hypothesize that the aggressive host immunogenic responses to CBM-containing allergens may arise from defense mechanisms originally directed against similar structures of pathogenic Ags.…”

Section: Discussionmentioning

confidence: 99%

Oxidized Cellulose Binding to Allergens with a Carbohydrate-Binding Module Attenuates Allergic Reactions

Shani

Shani²,

Shoseyov

et al. 2011

The Journal of Immunology

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Grass and mite allergens are of the main causes of allergy and asthma. A carbohydrate-binding module (CBM) represents a common motif to groups I (β-expansin) and II/III (expansin-like) grass allergens and is suggested to mediate allergen-IgE binding. House dust mite group II allergen (Der p 2 and Der f 2) structures bear strong similarity to expansin's CBM, suggesting their ability to bind carbohydrates. Thus, this study proposes the design of a carbohydrate-based treatment in which allergen binding to carbohydrate particles will promote allergen airway clearance and prevent allergic reactions. The aim of the study was to identify a polysaccharide with high allergen-binding capacities and to explore its ability to prevent allergy. Oxidized cellulose (OC) demonstrated allergen-binding capacities toward grass and mite allergens that surpassed those of any other polysaccharide examined in this study. Furthermore, inhalant preparations of OC microparticles attenuated allergic lung inflammation in rye grass-sensitized Brown Norway rats and OVA-sensitized BALB/c mice. Fluorescently labeled OC efficiently cleared from the mouse airways and body organs. Moreover, long-term administration of OC inhalant to Wistar rats did not result in toxicity. In conclusion, many allergens, such as grass and dust mite, contain a common CBM motif. OC demonstrates a strong and relatively specific allergen-binding capacity to CBM-containing allergens. OC's ability to attenuate allergic inflammation, together with its documented safety record, forms a firm basis for its application as an alternative treatment for prevention and relief of allergy and asthma.

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Microbial recognition of human cell surface glycoconjugates

Cited by 259 publications

References 53 publications

Non-association between anti-Toxoplasma gondii antibodies and ABO blood group system

Non-association between anti-Toxoplasma gondii antibodies and ABO blood group system

NEU1 Sialidase Expressed in Human Airway Epithelia Regulates Epidermal Growth Factor Receptor (EGFR) and MUC1 Protein Signaling

Oxidized Cellulose Binding to Allergens with a Carbohydrate-Binding Module Attenuates Allergic Reactions

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