Microbial production of xylitol and other polyols

Granström, Tom; Leisola, Matti

doi:10.1533/9780857093547.2.469

Cited by 1 publication

(1 citation statement)

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“…While XR from C. materiae prefers NADPH, XDH seems to prefer NAD + . NAD + cannot be regenerated in the absence of oxygen, and the imbalance of cofactors generated by that preference leads to cellular xylitol accumulation (Granström & Leisola 2013). The ability of yeasts to assimilate xylose was affected by the reduced oxygen availability, which might be associated to the limited NADPH supply required for XR activity.…”

Section: Discussionmentioning

confidence: 99%

Production of ethanol and xylitol from D-xylose by four strains of Candida (Spathaspora) materiae

MOURA,

PALLADINO,

CADETE

et al. 2023

An. Acad. Bras. Ciênc.

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Xylose is the most abundant pentose sugar in lignocellulosic biomass and can be biologically converted into economically important products by microorganisms such as yeasts. This study aimed to characterize the bioconversion of xylose into xylitol and ethanol using four strains of Candida materiae belonging to the Spathaspora clade, which includes yeast species with the potential to convert D-xylose to xylitol and ethanol. Fermentation assays were performed in YPX medium (yeast extract, peptone, xylose 5%) under two oxygen-limiting conditions at inoculum concentrations of 1, 5 and 10 g L -1 . The best results were obtained using a 5 g L -1 inoculum under moderate oxygenlimiting conditions. C. materiae UFMG-CM-Y480 produced 32.23 g L -1 of xylitol, yielding 0.743 g g -1 within 36 h. Different combinations of xylose and glucose (25/25 g L -1 , 40/10 g L -1 , 10/40 g L -1 ) were also used to verify the influence of sugars on C. materiae metabolism.Xylitol was preferentially produced in medium containing 40 g L -1 xylose. C. materiae UFMG-CM-Y480 produced 26.20 g L -1 of xylitol with a yield of 0.646 g g -1 in 36 h. Our results showed that C. materiae UFMG-CM-Y480 may convert D-xylose to xylitol with a better fermentative performance than other xylitol-producing yeasts.

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Section: Discussionmentioning

confidence: 99%