Microbial Production of Plant‐Derived Pharmaceutical Natural Products through Metabolic Engineering: Artemisinin and beyond

Dietrich, Jeffrey A.; Fortman, Jeffrey L.; Juminaga, Darmawi; Keasling, Jay D.

doi:10.1002/9781118028308.ch7

Cited by 2 publications

(3 citation statements)

References 60 publications

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“…In this regard, it is noteworthy that Amyris, Inc. is building a business for producing isoprenoid-based chemicals and fuels by reengineering the pathways and yeast chassis, or platform hosts, that were initially engineered to produce artemisinin. That is, engineering systems for high-titer isoprenoid production led not only to a new source of the antimalarial compound, but also enabled the construction of industrial biotechnology platforms with significant commercial value (Dietrich et al 2011). Separately, efforts to engineer synthetic biological systems to produce isoprenoid-based fuels such as bisabolene ) from renewable lignocellulosic materials (Bokinsky et al 2011) are now major projects of the US Department of Energy Joint BioEnergy Institute.…”

Section: Multi-use Platforms For Applied Synthetic Biologymentioning

confidence: 99%

“…Among the many other examples are systems for producing fatty-acids (Steen et al 2010), alkaloids (Dietrich et al 2011), polyketides (Keasling 2010) and utilizing nitrogen flux (Huo et al 2011). Notably, the development of efficient, scalable biosynthetic platforms also provides experimental testbeds for creating CAD tools and design-driven approaches (Carothers et al 2011) that reduce the demands for wet-lab infrastructure and repeated iterations of trialand-error optimization (Carothers et al 2009).…”

Section: Multi-use Is the Featurementioning

confidence: 99%

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Design-driven, multi-use research agendas to enable applied synthetic biology for global health

Carothers

2013

Syst Synth Biol

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Many of the synthetic biological devices, pathways and systems that can be engineered are multi-use, in the sense that they could be used both for commerciallyimportant applications and to help meet global health needs. The on-going development of models and simulation tools for assembling component parts into functionally-complex devices and systems will enable successful engineering with much less trial-and-error experimentation and laboratory infrastructure. As illustrations, I draw upon recent examples from my own work and the broader Keasling research group at the University of California Berkeley and the Joint BioEnergy Institute, of which I was formerly a part. By combining multi-use synthetic biology research agendas with advanced computer-aided design tool creation, it may be possible to more rapidly engineer safe and effective synthetic biology technologies that help address a wide range of global health problems.

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Section: Multi-use Platforms For Applied Synthetic Biologymentioning

confidence: 99%

Section: Multi-use Is the Featurementioning

confidence: 99%

Design-driven, multi-use research agendas to enable applied synthetic biology for global health

Carothers

2013

Syst Synth Biol

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“…An excellent example is artemisinin, traditionally derived from Artemisia annua 95, 96 and very recently, due to the application of genetic technologies, from microbial synthesis 97-100 . Traditional medicines containing A. annua have been used for thousands of years and as a consequence, the plant is important in healthcare, agriculture and commerce 101-103 .…”

Section: Introductionmentioning

confidence: 99%

21st Century natural product research and drug development and traditional medicines

Okogun²,

2013

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Natural products and related structures are essential sources of new pharmaceuticals, because of the immense variety of functionally relevant secondary metabolites of microbial and plant species. Furthermore, the development of powerful analytical tools based upon genomics, proteomics, metabolomics, bioinformatics and other 21st century technologies are greatly expediting identification and characterization of these natural products. Here we discuss the synergistic and reciprocal benefits of linking these ‘omics technologies with robust ethnobotanical and ethnomedical studies of traditional medicines, to provide critically needed improved medicines and treatments that are inexpensive, accessible, safe and reliable. However, careless application of modern technologies can challenge traditional knowledge and biodiversity that are the foundation of traditional medicines. To address such challenges while fulfilling the need for improved (and new) medicines - we encourage development of Regional Centres of ‘omics Technologies functionally linked with Regional Centres of Genetic Resources, especially in regions of the world where use of traditional medicines is prevalent and essential for health.

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Microbial Production of Plant‐Derived Pharmaceutical Natural Products through Metabolic Engineering: Artemisinin and beyond

Cited by 2 publications

References 60 publications

Design-driven, multi-use research agendas to enable applied synthetic biology for global health

Design-driven, multi-use research agendas to enable applied synthetic biology for global health

21st Century natural product research and drug development and traditional medicines

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