Microbial production of medium-chain length polyhydroxyalkanoates

Silva, Juliana B.; Pereira, João R.; Marreiros, Bruno C.; Reis, Maria A.M.; Freitas, Filomena

doi:10.1016/j.procbio.2021.01.020

Cited by 33 publications

(10 citation statements)

References 119 publications

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“…Various separation techniques have been proposed to extract the PHA granules from the cells [94][95][96][97]. For extensive reviews on the production and recovery of PHA from MMC, the following papers are suggested reading: [31,[98][99][100][101][102][103]. Here, we only focus on the production of crotonic acid from PHA as a downstream process to valorize the bio-based PHBV that is produced from wastewater and does not meet polymer market quality.…”

Section: Polyhydroxyalkanoates Production From Waste/wastewatermentioning

confidence: 99%

Recovery Techniques Enabling Circular Chemistry from Wastewater

et al. 2022

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In an era where it becomes less and less accepted to just send waste to landfills and release wastewater into the environment without treatment, numerous initiatives are pursued to facilitate chemical production from waste. This includes microbial conversions of waste in digesters, and with this type of approach, a variety of chemicals can be produced. Typical for digestion systems is that the products are present only in (very) dilute amounts. For such productions to be technically and economically interesting to pursue, it is of key importance that effective product recovery strategies are being developed. In this review, we focus on the recovery of biologically produced carboxylic acids, including volatile fatty acids (VFAs), medium-chain carboxylic acids (MCCAs), long-chain dicarboxylic acids (LCDAs) being directly produced by microorganisms, and indirectly produced unsaturated short-chain acids (USCA), as well as polymers. Key recovery techniques for carboxylic acids in solution include liquid-liquid extraction, adsorption, and membrane separations. The route toward USCA is discussed, including their production by thermal treatment of intracellular polyhydroxyalkanoates (PHA) polymers and the downstream separations. Polymers included in this review are extracellular polymeric substances (EPS). Strategies for fractionation of the different fractions of EPS are discussed, aiming at the valorization of both polysaccharides and proteins. It is concluded that several separation strategies have the potential to further develop the wastewater valorization chains.

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Section: Polyhydroxyalkanoates Production From Waste/wastewatermentioning

confidence: 99%

Recovery Techniques Enabling Circular Chemistry from Wastewater

et al. 2022

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“…The Chang group reported an isolation of the previously known compounds 11-epichaetomugilin I, chaetomugilin I, and chaetomugilin F (Figure 3) from endophytic fungus Chaetomium globosum [110], which has been described as a symbiotic microorganism associated with several marine macroorganisms (reviewed in [111]). These molecules have been previously described by other groups [112][113][114].…”

Section: Other Moleculesmentioning

confidence: 99%

Recent Updates on Marine Cancer-Preventive Compounds

Dyshlovoy

2021

Marine Drugs

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The natural compounds derived from marine organisms often exhibit unique chemical structures and potent biological activities. Cancer-preventive activity is one of the rather new activities that has emerged and been extensively studied over the last decades. This review summarizes the recent updates on the marine chemopreventive compounds covering the relevant literature published in 2013–2021 and following the previous comprehensive review by Stonik and Fedorov (Marine Drugs 2014, 12, 636–671). In the current article, only the molecules having an effect on malignant transformation (or related pathway and molecules), cancer stem cells, or carcinogen-induced in vivo tumor development were considered to be “true” cancer-preventive compounds and were, therefore, reviewed. Additionally, particular attention has been given to the molecular mechanisms of chemoprevention, executed by the reported marine compounds.

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“…Polyhydroxyalkanoates (PHAs) are an interesting family of biopolymers that has attracted much attention in recent decades due to their natural origin, biodegradability, biocompatibility, and comparable physicochemical, thermal, and mechanical properties to some commodity plastics such as polyolefins [6]. PHAs can be synthesized by a wide range of microorganisms as carbon and energy reserve materials in the form of intracellular granules under metabolic stress conditions in the presence of a carbon source in excess [7,8]. Due to their bacterial origin, they can be metabolized by a multitude of microorganisms, showing high biodegradation rates in all environments including soil and marine [9,10].…”

Section: Introductionmentioning

confidence: 99%

In Service Performance of Toughened PHBV/TPU Blends Obtained by Reactive Extrusion for Injected Parts

et al. 2022

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Moving toward a more sustainable production model based on a circular economy, biopolymers are considered as one of the most promising alternatives to reduce the dependence on oil-based plastics. Polyhydroxybutyrate-co-valerate (PHBV), a bacterial biopolyester from the polyhydroxialkanoates (PHAs) family, seems to be an attractive candidate to replace commodities in many applications such as rigid packaging, among others, due to its excellent overall physicochemical and mechanical properties. However, it presents a relatively poor thermal stability, low toughness and ductility, thus limiting its applicability with respect to other polymers such as polypropylene (PP). To improve the performance of PHBV, reactive blending with an elastomer seems to be a proper cost-effective strategy that would lead to increased ductility and toughness by rubber toughening mechanisms. Hence, the objective of this work was the development and characterization of toughness-improved blends of PHBV with thermoplastic polyurethane (TPU) using hexamethylene diisocyanate (HMDI) as a reactive extrusion agent. To better understand the role of the elastomer and the compatibilizer, the morphological, rheological, thermal, and mechanical behavior of the blends were investigated. To explore the in-service performance of the blends, mechanical and long-term creep characterization were conducted at three different temperatures (−20, 23, 50 °C). Furthermore, the biodegradability in composting conditions has also been tested. The results showed that HMDI proved its efficiency as a compatibilizer in this system, reducing the average particle size of the TPU disperse phase and enhancing the adhesion between the PHBV matrix and TPU elastomer. Although the sole incorporation of the TPU leads to slight improvements in toughness, the compatibilizer plays a key role in improving the overall performance of the blends, leading to a clear improvement in toughness and long-term behavior.

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Microbial production of medium-chain length polyhydroxyalkanoates

Cited by 33 publications

References 119 publications

Recovery Techniques Enabling Circular Chemistry from Wastewater

Recovery Techniques Enabling Circular Chemistry from Wastewater

Recent Updates on Marine Cancer-Preventive Compounds

In Service Performance of Toughened PHBV/TPU Blends Obtained by Reactive Extrusion for Injected Parts

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