Microbial metabolites diversity and their potential as molecular template for the discovery of new fluorescent and radiopharmaceutical probes

New hybrid radio-fluorescent probes [131I]-BPF-01 and [131I]-BPF-02 for visualisation of cancer cells: Synthesis and preliminary in vitro and ex vivo evaluations

“…Moreover, the application of fluorescent imaging offers several advantages (e.g., low cost of instrumentations and portability and real-time capabilities). Nevertheless, its widespread use is limited by light scattering and low tissue penetration [ 16 , 17 ]. To overcome these issues, several probes containing hybrid radioactive material and fluorescent agents have been developed, inspired by the fact that these two modalities could provide complementary imaging information.…”