Microbial Metabolites as Potentially useful Pharmacologically active Agents

Perlman, D.; Peruzzotti, George

doi:10.1016/s0065-2164(08)70587-2

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Applications Of the New Genetics1

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1992

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Cited by 10 publications

(1 citation statement)

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“…A new approach in the pharmaceutical field is to apply microbial secondary metabolites to diseases that are not caused by other bacteria or fungi (52,53). For years, major drugs such as hypertensive and anti-inflammatory agents that are used for noninfectious diseases have been strictly synthetic products.…”

Section: Applications Of the New Geneticsmentioning

confidence: 99%

Industrial Microbiology

Demain

1981

Science

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Industrial microbiology has served humanity since prebiblical times, providing fermented beverages and foods to enhance the quality of life. The antibiotic era featured an explosion in the number of microbial products for medicine, nutrition, industry, and research. Revolutionary developments in molecular genetics are propelling the field into a new growth phase with promise of solutions to major world problems.

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Section: Applications Of the New Geneticsmentioning

confidence: 99%

Industrial Microbiology

Demain

1981

Science

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Mutterkornalkaloide und Weitere Pharmakologisch Aktive Substanzen

Rehm

1980

Industrielle Mikrobiologie

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Trends in the search for bioactive microbial metabolites

Ōmura

1992

Journal of Industrial Microbiology

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Bioactive microbial metabolites are attracting increasing attention as useful agents for medicine, veterinary medicine, agriculture, and as unique biochemical tools. A review of the current trends in the discovery of new metabolites shows that the number of active compounds with non-antibiotic type of activity has increased, resulting in an expansion of the variety of bioactivity of microbial metabolites. Factors that contribute to the increased rate of discovery include: development of new methods for activity measurement, exploitation of novel groups of microorganisms as sources of active compounds, new directions for chemical modification, and incorporation of newer knowledge of biotechnology into screening systems. To exemplify this, typical screening methods, and chemical and biological properties of several bioactive compounds obtained by these methods are discussed.

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Microbial Metabolites as Potentially useful Pharmacologically active Agents

Cited by 10 publications

References 95 publications

Industrial Microbiology

Industrial Microbiology

Mutterkornalkaloide und Weitere Pharmakologisch Aktive Substanzen

Trends in the search for bioactive microbial metabolites

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