Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans

Han, Nathan D.; Cheng, Jiye; Delannoy-Bruno, Omar; Webber, Daniel; Terrapon, Nicolas; Henrissat, Bernard; Rodionov, Dmitry A.; Arzamasov, Aleksandr A.; Osterman, Andrei L.; Hayashi, David K.; Meynier, Alexandra; Vinoy, Sophie; Desai, Chandni; Marion, Stacey; Barratt, Michael J.; Heath, Andrew C.; Gordon, Jeffrey I.

doi:10.1016/j.cell.2022.06.004

Cited by 41 publications

(22 citation statements)

References 98 publications

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“…Studies have shown that tryptophan metabolites, such as indolelactic acid, indolepyruvate, and N -methylserotonin affect host adiposity, immunity, metabolism, and gut motility, which plays an important role in intestinal and/or liver health. 52,53 Collectively, these results indicate that E10, MF, and LGGF pretreatment can effectively and differentially reverse the alcohol-induced changes in the gut microbial metabolic profile. As the tryptophan metabolites, indolelactic acid, indolepyruvate, N -methylserotonin, and N -methyltryptamine may be important metabolites for the gut–liver interaction, which may regulate the intestinal microbiota and inhibit inflammation in the gut and liver.…”

Section: Discussionmentioning

confidence: 79%

Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice

Duan,

Zhou,

Ren

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 79%

Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice

Duan,

Zhou,

Ren

et al. 2024

Food Funct.

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“…The title compound is the mono-methylated variant 5-hydroxy-N-methyltryptamine, which is a naturally occurring derivative of serotonin that has garnered attention due to its potential applications in biological and medical contexts. Endogenous N-methyl-data reports serotonin has been observed both in plants and mammals, including in rodents colonized with human gut bacterial strains (Han et al, 2022). The biosynthesis of N-methylserotonin most likely occurs via N-methylation of serotonin by the enzyme indolethylamine-N-methyltransferase (Thompson et al, 2001).…”

Section: Structure Descriptionmentioning

confidence: 99%

N-Methylserotonin hydrogen oxalate

Naeem,

Anas,

Chadeayne

et al. 2023

IUCr Data

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The solid-state structure of N-methylserotonin {systematic name: [2-(5-hydroxy-1H-indol-3-yl)ethyl](methyl)azanium hydrogen oxalate}, C11H15N2O+·C2HO4 −, is reported. The structure possesses a singly protonated N-methylserotonin cation and one hydrogen oxalate anion in the asymmetric unit. In the crystal, the molecules are linked by N—H...O and O—H...O hydrogen bonds into a three-dimensional network.

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“…However, as the functional ingredients can be directly obtained from the diet, the extraction of polysaccharides from edible plant or organisms that needs considerable energy expenditure is not recommended. Furthermore, Han et al ( 130 ) reported that the functional ingredients of N-methylserotonin from orange fibers by-products were released by intestinal microbiota, which might be disposed of in the extraction process. Therefore, additional efforts are needed to identify functional polysaccharides from non-edible dietary by-products.…”

Section: Limitations and Perspectivesmentioning

confidence: 99%

Polysaccharides influence human health via microbiota-dependent and -independent pathways

2022

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Polysaccharides are the most diverse molecules and can be extracted from abundant edible materials. Increasing research has been conducted to clarify the structure and composition of polysaccharides obtained from different materials and their effects on human health. Humans can only directly assimilate very limited polysaccharides, most of which are conveyed to the distal gut and fermented by intestinal microbiota. Therefore, the main mechanism underlying the bioactive effects of polysaccharides on human health involves the interaction between polysaccharides and microbiota. Recently, interest in the role of polysaccharides in gut health, obesity, and related disorders has increased due to the wide range of valuable biological activities of polysaccharides. The known roles include mechanisms that are microbiota-dependent and involve microbiota-derived metabolites and mechanisms that are microbiota-independent. In this review, we discuss the role of polysaccharides in gut health and metabolic diseases and the underlying mechanisms. The findings in this review provide information on functional polysaccharides in edible materials and facilitate dietary recommendations for people with health issues. To uncover the effects of polysaccharides on human health, more clinical trials should be conducted to confirm the therapeutic effects on gut and metabolic disease. Greater attention should be directed toward polysaccharide extraction from by-products or metabolites derived from food processing that are unsuitable for direct consumption, rather than extracting them from edible materials. In this review, we advanced the understanding of the structure and composition of polysaccharides, the mutualistic role of gut microbes, the metabolites from microbiota-fermenting polysaccharides, and the subsequent outcomes in human health and disease. The findings provide insight into the proper application of polysaccharides in improving human health.

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Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans

Cited by 41 publications

References 98 publications

Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice

Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice

N-Methylserotonin hydrogen oxalate

Polysaccharides influence human health via microbiota-dependent and -independent pathways

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