Microbial Keratitis in Patients With Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Experience From a Tertiary Centre in Taiwan

Tsai, Tsung‐Ying; Adiyabazar, Doyodmaa; Hsiao, Ching-Hsi; Pan, Li-Yen; Chen, Shin‐Yi; Tsai, Yueh-Ju; Chen, Chun‐Bing; Chung, Wen‐Hung; Hui‐Kang, David

doi:10.1097/ico.0000000000003063

Cited by 1 publication

(1 citation statement)

References 39 publications

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“…Major interest to date centers around countries (particularly in Asia) [44,45] which experience high levels of pollutants, which are becoming more prevalent globally. This often leads to the development of dry eye [46][47][48][49] and its consequences, which include a higher risk for microbial keratitis [50,51]. In South Korea, for example, this was documented in humans [9] who experienced increased visits to the emergency room for conjunctivitis and keratitis.…”

Section: Discussionmentioning

confidence: 99%

Impact of Airborne Exposure to PM10 Increases Susceptibility to P. aeruginosa Infection

McClellan,

Wright,

Muhammed

et al. 2024

IJERPH

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The effects of exposure to airborne particulate matter with a size of 10 μm or less (PM10) on C57BL/6 mouse corneas, their response to Pseudomonas aeruginosa (PA) infection, and the protective effects of SKQ1 were determined. C57BL/6 mouse corneas receiving PBS or SKQ1 were exposed to control (air) or PM10 for 2 weeks, infected, and the disease was documented by clinical score, PMN quantitation, bacterial plate count, RT-PCR and Western blot. PBS-treated, PM10-exposed corneas did not differ at 1 day postinfection (dpi), but exhibited earlier (3 dpi) corneal thinning compared to controls. By 3 dpi, PM10 significantly increased corneal mRNA levels of several pro-inflammatory cytokines, but decreased IL-10, NQO1, GR1, GPX4, and Nrf2 over control. SKQ1 reversed these effects and Western blot selectively confirmed the RT-PCR results. PM10 resulted in higher viable bacterial plate counts at 1 and 3 dpi, but SKQ1 reduced them at 3 dpi. PM10 significantly increased MPO in the cornea at 3 dpi and was reduced by SKQ1. SKQ1, used as an adjunctive treatment to moxifloxacin, was not significantly different from moxifloxacin alone. Exposure to PM10 increased the susceptibility of C57BL/6 to PA infection; SKQ1 significantly reversed these effects, but was not effective as an adjunctive treatment.

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