Microbial interactions trigger the production of antibiotics

Netzker, Tina; Flak, Michal; Krespach, Mario K. C.; Stroe, Maria C.; Weber, Jakob; Schroeckh, Volker; Brakhage, Axel A.

doi:10.1016/j.mib.2018.04.002

Cited by 95 publications

(73 citation statements)

References 66 publications

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“…Recent studies regarding the biodegradation of dyes in TWWs using bacterial consortia are reported in Table 2. The bacterial decolorization can be directly influenced by various factors 78,79 such as the level of agitation, oxygen, temperature, pH, dye structure, dye concentration, supplementation of different carbon and nitrogen sources, electron donor, redox mediator 80,81 and salt concentrations. Therefore, acclimatized bacteria, isolated from dye contaminated sites, are very efficient in removal process due to adaption to different extreme environmental conditions.…”

Section: Pure Culturementioning

confidence: 99%

Untitled

2019

JTEFT

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Textile dyeing industries are facing problems to meet the green practices standards for safe discharge of wastewater due to its complex nature. TWWs are a complex mixture of salts, acids, heavy metals, organ-chlorine-based pesticides, pigments and dyes. 5,10 TWWs generated from the different wet processes are characterized by high pH, temperature, BOD, COD, detergents, surfactants, suspended and dissolved solids, dispersants, leveling agents, toxic organics, chlorinated compounds, sulphide and formaldehyde, may be added to improve dye adsorption onto the fibers 9 and more details are mentioned in the Figure 1. Such effluents are also characterized by the presence of heavy metals, such as Cr, Zn, Cu and Al due to metal-based complexes dyes. 10,14 The most common textile operates are desizing, bleaching, mercerizing, dyeing and finishing. 15 Characteristics and the amount of TWWs depend to the process, dyeing is the most one which requires large volumes of water not only in the step of adding color to the fibers, in dye bath, but also during the rinsing step. Mercerizing and finishing are also significant generators of TWWs. In addition, equipment, machines and chemicals, 5 such as detergents and stabilizers, alter significantly the nature of TWWs. Another important factor which contributes to the ecotoxicity and the volume of TWWs is that dyeing and finishing processes, especially, require the imput of a wide range of dyestuffs. The Variety of dyes depends to the fiber used. 16 For example, cellulose fiber requires the application of direct, reactive, vat, azo or sulfide dyes. Acid dyes are used essentially for wool and silk. Azo and disperse dyes are applied to the polyester fiber. A large quantity of these dyes is released in the TWWs due to their degree of fixation to fibers. AbstractThe textile wastewaters (TWWs) are one of the major sources of environmental pollution, due to the presence of various recalcitrant dyes. It is estimated that about 300,000 t of synthetic dyes are discharged in TWWs every year worldwide. Thus, untreated or incompletely treated TWWs cause harm to aquatic and terrestrial life. To avoid the negative impacts associated to the discharge of TWWs into the natural ecosystems, effective dye remediation processes are being developed. Current methods of removing dyes from TWWs are generally regarded to be complex, expensive and energy demanding processes. Therefore, bioremediation of TWWs using microbial consortia has appeared as an emerging alternative for textile dyes removal. This chapter provides an updated literature on the application of microbial consortia in the treatment of TWWs, focusing on the mechanisms involved in dye biodegradation and the main interactions established between the consortia members and how they can influence dye removal efficiencies.

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Section: Pure Culturementioning

confidence: 99%

Untitled

2019

JTEFT

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“…[8] One of the current considerations is to regardS Ms as communication and signaling moleculesf or intra/inter-species chemical communication at sub-inhibitory concentrations. [12] Furthermore, co-culture is capable of mimicking interactions within natural microbial communities. [10] To date,m ost SMs have been isolated from bacteria and fungi.F romt he perspective of geneticr esources, Cimermancic et al predictedt hat at otal of 33,351 putative biosynthetic gene clusters (BGCs) exist in 1154 sequenced prokaryotic genomes.…”

Section: Introductionmentioning

confidence: 99%

“…Compared to laboriousg eneticm anipulations, co-culture of different microorganisms is am ore promising and effective methodt oa ctivate the production of novel SMs. [12] Furthermore, co-culture is capable of mimicking interactions within natural microbial communities. Investigating the impacts of chemicalo rp hysical interspecies interactions on microbial secondary metabolism and the detailsofc hemical communication processes mediated by SMs is af ocus of current research.…”

Section: Introductionmentioning

confidence: 99%

Cryptic Chemical Communication: Secondary Metabolic Responses Revealed by Microbial Co‐culture

Liu

Kakeya

2020

Chemistry An Asian Journal

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Microbial secondary metabolites (SMs) have long been viewed as as ignificants ource of novel pharmaceutical and agrochemical molecules. With the increasing availability of genomic data, numerous biosynthetic gene clusters (BGCs) have been discovered. Despite the presence of tens of thousands of BGCs that can theoretically produce extremely diverse SMs, many gene clusters remain in as ilent state under axenic culture conditions. Co-culture is ap romising research approach as it stimulates the expression of cryptic BGCs to produce novel metabolites and also mimics naturali nterspeciesi nteractions in al aboratory environment. In recenty ears, the roles of SMs in microbial communication have caught the attention of researchers and our understanding of microbes and their productiono fr emarkable SMs has improved. SMs may be extensively involved in av ariety of communication eventsa mong microorganisms. We herein summarize certainr epresentative findings in the field of chemical communication involving SMs in co-culture systems.

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“…Metagenomic analysis that handles the collection of microorganisms as a whole revealed a huge number of novel genes with unknown functions [Proctor et al, 2019;Barko et al, 2018;Nishijima et al, 2016]. Particular interest resides in the gradual and steady flows of finding that a combination of microorganisms, or microbial consortium, exhibits novel effects that could not be expected from monocultures [Tsoi et al, 2019;Tanoue et al, 2019;Atarashi et al, 2013;Netzker et al, 2018]. A mixture of selected 17 Clostridia strains is a prerequisite for maximum Treg induction, with its subset being less active [Atarashi et al, 2013].…”

Section: Introductionmentioning

confidence: 99%

The Life Cycle of <b><i>Dictyostelium discoideum</i></b> Is Accelerated via MAP Kinase Cascade by a Culture Extract Produced by a Synthetic Microbial Consortium

Kuwayama

Higashinakagawa

2019

Microb Physiol

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A cellular slime mold, Dictyostelium discoideum, is an amoeboid organism that has a unique life cycle consisting of distinctly separated vegetative and developmental phases. Thus, this organism presents a rare opportunity in which to examine the effects of bioactive substances on separate cellular activities. In this research, we investigated the effect of a culture extract, termed EMXG, produced by a synthetic microbial consortium. EMXG promoted proliferative response of amoeba cells. It further accelerated the developmental phase, leading to the preferred fruiting body formation from fewer cells. Furthermore, EMXG modulated biological rhythm of this organism, that is, interval of oscillation of cAMP level observed in suspension starvation was significantly shortened. Concomitantly, the level of ERKB, a MAP kinase, was found to oscillate in a similar fashion to that of cAMP. Additionally, ErkB-deficient mutant amoeboid cells did not respond to proliferative stimulation by EMXG. These lines of evidence point to a likelihood that MAP kinase cascade is involved and further that ErkB could be the molecular target of EMXG.

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Microbial interactions trigger the production of antibiotics

Cited by 95 publications

References 66 publications

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Cryptic Chemical Communication: Secondary Metabolic Responses Revealed by Microbial Co‐culture

The Life Cycle of <b><i>Dictyostelium discoideum</i></b> Is Accelerated via MAP Kinase Cascade by a Culture Extract Produced by a Synthetic Microbial Consortium

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