Microbial Hosts as a Promising Platform for Polyphenol Production

Braga, Adelaide; Rocha, Isabel; Faria, Nuno

doi:10.1007/978-981-13-7154-7_3

Cited by 6 publications

(4 citation statements)

References 163 publications

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“…Over the last two decades, the biotechnological production of natural compounds has increased and has become promising for enabling the formation of aromatic compounds. Another factor that corroborates the rise of and interest in biotechnological processes for the production of aromas is the possibility of using agro-industrial residues that are rich in monoterpenoid compounds, since these can be used as substrates for biotransformation (Bicas et al 2008a;Fanaro et al 2016;Sharma et al 2020).…”

Section: Limonene and Pinene As Substrates For Fungal Biotransformationmentioning

confidence: 86%

“…The products obtained through this approach can be considered to be natural, and related to the concept of sustainable development, since such production processes are aligned with the best practices in environmental preservation (Oliveira Felipe, Oliveira and Bicas 2017) Over the past decade, microbial biotransformations have gained importance. This biotechnology process can be de ned as the use of biological systems to catalyze chemical changes in substances that do not constitute their common precursor (substrate) (Carvalho 2016;Fanaro et al 2016). In vitro biotransformation can be carried out under mild conditions and with high selectivity, and includes regio-, stereo-, and enantioselectivity modi cations of a substrate based on single or multistep reactions catalyzed by biological systems within microbial cells (bacteria, yeasts and fungi) or with pure enzymes (Molina et al 2014a;Bicas et al 2016e;Sales et al 2018a).…”

Section: Introductionmentioning

confidence: 99%

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Fungal biotransformation of limonene and pinene as a biotechnological approach for production of aroma compounds

Sevalho

Paulino

Souza

et al. 2021

Preprint

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The number of aroma compounds obtained by biotechnological process has increased tremendously in recent years and, as a result, are now being extensively employed in order to make products more attractive for consumers. In the present review, we inten to assess the wide range of reactions are catalyzed by fungal strains in regards to biotransformation of limonene and pinene for the aroma compounds production, their production rates/maximum concentrations and their biological potential. We comprehensively summarized in this review available data (2000–2021) regarding fungal biotransformation of limonene and pinene as biotechnological processes. Over the past years, has been paid to the biotransformation processes due to mild and environmentally friendly conditions applied. This review has shown that reports on the application of the fungi as a promising source of biocatalysts, mainly for stereoselective reactions such as hydroxylation and epoxidation. Studies have demonstrated the existence of promising monoterpenes used as substrates, which could be important from an industrial standpoint since this increases their importance as starting materials for obtaining aromatic molecules new. Moreover, biological (e.g.,antioxidant, anticancer) activities attributed to some monoterpene biotransformation products are increasingly being reported, indicating that their applications may transcend food, cosmetic and pharmaceutical industry.

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Section: Limonene and Pinene As Substrates For Fungal Biotransformationmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Fungal biotransformation of limonene and pinene as a biotechnological approach for production of aroma compounds

Sevalho

Paulino

Souza

et al. 2021

Preprint

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“…Genetically modified microorganisms have several advantages since they can grow in inexpensive substrates, are easier to manipulate and have fast production cycles allowing a faster and larger production. The use of microorganisms allows large-scale fermentations and the downstream purification processes become easier due to the absence of competing pathways [44]. Moreover, microorganisms have a primary metabolism similar to plants being able to provide the aromatic amino acids and malonyl-CoA as precursor molecules.…”

Section: Polyphenol Heterologous Productionmentioning

confidence: 99%

Synthetic Biology Approaches to Engineer Saccharomyces cerevisiae towards the Industrial Production of Valuable Polyphenolic Compounds

Rainha

Gomes

Rodrigues

et al. 2020

Life

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Polyphenols are plant secondary metabolites with diverse biological and potential therapeutic activities such as antioxidant, anti-inflammatory and anticancer, among others. However, their extraction from the native plants is not enough to satisfy the increasing demand for this type of compounds. The development of microbial cell factories to effectively produce polyphenols may represent the most attractive solution to overcome this limitation and produce high amounts of these bioactive molecules. With the advances in the synthetic biology field, the development of efficient microbial cell factories has become easier, largely due to the development of the molecular biology techniques and by the identification of novel isoenzymes in plants or simpler organisms to construct the heterologous pathways. Furthermore, efforts have been made to make the process more profitable through improvements in the host chassis. In this review, advances in the production of polyphenols by genetically engineered Saccharomyces cerevisiae as well as by synthetic biology and metabolic engineering approaches to improve the production of these compounds at industrial settings are discussed.

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“…Furthermore, ROS can play a regulatory role in activating pro-inflammatory cytokines and inflammasomes while conversely, excessive activation of the inflammatory response can stimulate ROS synthesis [2, 3]. Since natural bioactive metabolites are considered safer and more suitable options, there is an unprecedented increase in the commercial demand for such compounds [4]. Consequently, it becomes necessary to seek sustainable sources of potent and effective bioactive compounds that can provide low-cost therapeutic options.…”

Section: Introductionmentioning

confidence: 99%

Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

Sharma,

Agarwal,

Bhardwaj

et al. 2024

Preprint

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Endophytes share a complex intimate relationship due to which they are capable of synthesizing metabolites that are either similar or derivative of host bioactive compounds. Such endophytes especially from medicinal plants can be prospected for commercial-scale production of the therapeutic compound. Thus, the study evaluates the antioxidant and anti-inflammatory potential of Momordica charantia fruit endophyte Bacillus haynesii R2MCFF61, and determines its metabolite profile through LC-Q-TOF-MS for the bioactive compounds produced. B. haynesii R2MCFF61 showed significant antioxidant and anti-inflammatory potential with increased DPPH scavenging activity in the standard compound and inhibition of protein denaturation respectively. The metabolic profile of this endophyte showed 23 compounds, mostly consisting of metabolites from lipid, phenylpropanoid and triterpenoid pathways. B. haynesii R2MCFF61 showed production of cucurbitane-triterpenoids namely Momordicoside K, 19-dimethoxycucurbita-5(10),6,22(E),24-tetraen-3β-ol and 23(E)-7β-methoxycucurbita-5,23,25-trien-3β-ol. These compounds are mainly produced by M. charantia fruit and their production by its endophyte is reported for the first time. Thus, these results indicate the promising therapeutic potential of B. haynesii R2MCFF61 which can be utilized as a low-cost sustainable source of these bioactive compounds.

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Microbial Hosts as a Promising Platform for Polyphenol Production

Cited by 6 publications

References 163 publications

Fungal biotransformation of limonene and pinene as a biotechnological approach for production of aroma compounds

Fungal biotransformation of limonene and pinene as a biotechnological approach for production of aroma compounds

Synthetic Biology Approaches to Engineer Saccharomyces cerevisiae towards the Industrial Production of Valuable Polyphenolic Compounds

Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

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