Microbial genetic engineering approach to replace shark livering for squalene

Patel, Alok; Bettiga, Maurizio; Christakopoulos, Paul

doi:10.1016/j.tibtech.2022.03.008

Cited by 27 publications

(17 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conventional medicines are ingredients in the form of plant ingredients, animal ingredients, mineral ingredients, herbal preparations, or mixtures of these ingredients, which have been used for generations for treatment based on experience [11]. One of the traditional medicines often used is bottled shark liver oil [12]. Shark oil is a medicine to reduce burns, heart disease, cancer, and infertility.…”

Section: General Environmental Conditionsmentioning

confidence: 99%

Pid-Based Bottle Shark Heart Heater Design and Development

Irwandy

Asran

Munir

et al. 2023

Int. J. Eng. Scie. and Inform. Technology.

View full text Add to dashboard Cite

Traditional medicines are ingredients or ingredients in the form of plant ingredients, animal ingredients, mineral ingredients, galenic preparations, or mixtures of these materials, which have been used for generations for treatment and can be applied according to the norms in force in society. Bottle shark (Centrophorus atromarginatus) has good prospects as a producer of liver oil; this fish is easy to catch and occurs in relatively large quantities in Indonesian waters. The catch rate until now is only 39% of its sustainable potential. Bottled shark liver oil contains 90% squalene, Vitamin A, and Omega, which are very useful for the human body as a supplement for heart disease and stomach ulcers and increase stamina and brain intelligence. The rapid Development of technology certainly benefits the people who use it. One example of today's use of technology is applying a technology system for the fisheries sector. This tool works automatically to monitor the processing of bottled shark livers. That way, fishermen don't have to worry about cloudy weather or things that will take longer than processing the shark liver bottle. This Bottle Shark Liver Heater uses temperatures at 31˚, 32˚, 33˚, 34˚, and 35˚. With PID (Proportional Integral Derivative) control, the quality of the Bottle Shark liver can be maintained. This tool is supported by a DS18B20 temperature sensor, Arduino uno, Relay, Ceramic Heater element, DC Fan, LCD 16X12, Power Supply, and Switch. It is hoped that the community, with this automatic system device, can make it easier to manage Bottle Shark Liver Oil.

show abstract

Section: General Environmental Conditionsmentioning

confidence: 99%

Pid-Based Bottle Shark Heart Heater Design and Development

Irwandy

Asran

Munir

et al. 2023

Int. J. Eng. Scie. and Inform. Technology.

View full text Add to dashboard Cite

show abstract

“…Elucidation of carotenoids production in bacteria, algae, protist (Patel et al, 2022) and higher plants has progressed significantly, and it is expected that primary carotenoids biosynthesis in these species follows a similar process. Figure 1 depicts the lutein synthesis route in green algae (Chlorophyta), which is subdivided into the different stages (Huang et al, 2021;Kato et al, 2021;Lou et al, 2021;Xie et al, 2021;Song et al, 2022;Velmurugan and Kodiveri Muthukaliannan, 2022).…”

Section: Biosynthesis Of Lutein In Microalgae By Native Pathwaymentioning

confidence: 99%

Microalgal lutein biosynthesis: Recent trends and challenges to enhance the lutein content in microalgal cell factories

2022

Self Cite

View full text Add to dashboard Cite

Photosynthetic organisms such as eukaryotic microalgae and prokaryotic cyanobacteria synthesize a wide range of valuable chemicals. They are predicted to become efficient and renewable sources for valuable products in the future due to their high biomass synthesis using CO2 and solar energy. Microalgae are producers of several carotenoids including lutein, which is a xanthophyll carotenoid with several health advantages, including the prevention of age-related macular degeneration. Currently, it is extracted on commercial scale from marigold flower petals, however, production from plant sources is highly affected by seasonal variations, requires arable land, and has high production cost. Microalgae, on the other hand, are an ideal alternative for lutein synthesis due to their rapid growth and high biomass and lutein yield. It is, however, necessary to further improve lutein productivity, for a successful transition to commercial production. This article describes lutein biosynthesis in microalgae by using their native biochemical pathways, as well as possible target genes for genetic engineering to enhance lutein production. Understanding the processes behind lipid droplet synthesis in chloroplasts, as well as carotenoid transport across chloroplast membranes and carotenoid esterification, might lead to novel ways to boost lutein levels in microalgae.

show abstract

“…In recent years, marine and salt‐tolerant microorganisms such as thraustochytrids have gained significant attention as promising multi‐product single‐cell biorefinery due to their ability to accumulate a high lipid content, wide substrate range, salt‐tolerance and production of oleochemicals [carotenoids, squalene, long‐chain polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA)] (Aasen et al, 2016; Patel, Bettiga, et al, 2022a). PUFAs cannot be synthesized by humans naturally, making them one of the essential fatty acids which in turn resulted in increased market value.…”

Section: Current Management Of Hydrophobic Wastes and Their Utilizati...mentioning

confidence: 99%