Microbial fuel cells (MFC) are a promising technology to enhance the power-efficiency of municipal sewage plants. Therefore, the possibilities of MFC implementation on municipal sewage treatment plants are analyzed in this contribution.A newly developed up-scaled cell design is described, each with an active area of 6,200 square centimeters respectively. The cell design integrates a double-sided graphite/polymer composite anode between two oxygen reducing cathodes, to enlarge the active surface area. Furthermore, the new design integrates in-situ electrode potential measurement by a reference electrode and biofilm flushing by nitrogen purge.To reach a uniform anolyte overflow, novel anodic flow patterns are described, evaluated by computational fluid dynamics.In addition to the technical cell design, the first prototype is presented. All cell elements are manufactured in an economical serial production, as well as high performance catalytic active cathodes, which are produced in-house by a semi-automatic production line.