Microbial Findings in Cancers of the Breast and in Their Metastases to the Skin

Abstract

In four cases of carcinoma of the breast, variably acid-fast coccoid forms were found in sections from their metastases to the skin and in one of these cases in sections of the primary carcinoma. In this one case, similar-appearing corcoid forms were observed within the sections of the primary malignancy. In this same case, Staphylococcus epidermidis was cultured and studied at once and as it aged for development of forms comparable to those found in the microscopic sections of the neoplastic process. The implications of the findings for etiology of carcinoma of the breast are discussed.

The ovarian cancer oncobiome

“…Among the bacterial genera detected in the ovarian cancer, many have been reported earlier to be either associated with other types of cancers [19–31], for example: Streptococcus , Staphylococcus , Bacillus , Mycoplasma , Chlamydophila in lung cancer [19, 22]; Pediococcus in pancreatic cancer [19, 23]; Staphylococcus, Mycoplasma and Chyseobacterium in breast cancer [19, 24, 25]; Fusobacterium and Prevotella in oral cancer [19, 26] ; Salmonella in gall bladder cancer [19, 27]; Chlamydia in Pulmonary Mucosa-Associated lymphoid tissue lymphoma [19, 28]; Streptococcus , Fusobacterium , Escherichia and Mycoplasma in colorectal cancer [19, 25, 29–31]. ; as well as Treponema and Streptococcus in oesophageal cancer [21].…”

Exploring the link between microorganisms and oral cancer: A systematic review of the literature

“…In additional to epidemiological data about specific bacterial species and types of cancer, the idea that bacteria can live and even thrive within human tumors has been recognized for more than 70 years. Since 1931 there have been countless reports of large numbers of viable bacteria present in various types of malignant tumor excised from patients 32–34. More recently, using bacteria labeled with light‐emitting proteins, several species have been shown to successfully survive and propagate within solid tumors in animal models 35.…”

Necroscopic Findings of Pleomorphic, Variably Acid‐Fast Bacteria in a Fatal Case of Kaposi's Sarcoma

“…Although highly controversial, studies by a number of different investigators have suggested that pleomorphic acid‐fast bacteria (possibly in a cell‐wall‐deficient, L form phase) may be associated with malignancy 8–15 and also with certain collagen diseases 18–20 . Possibly relevant to these studies are recent reports that indicate that cell‐wall‐deficient forms of staphylococcal, streptococcal, and corynebacteria‐like organisms may be universally present in the bloodstream of human beings 21–24 .…”