Microbial epidemiology and clinical risk factors of carbapenemase-producing Enterobacterales amongst Irish patients from first detection in 2009 until 2020

O’Connell, Nuala H.; Gasior, S.; Slevin, B; Power, Lorraine; Barrett, Stephen; Bhutta, S.I.; Minihan, B; Powell, James; Dunne, Colum P.

doi:10.1016/j.infpip.2022.100230

Cited by 1 publication

(1 citation statement)

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“…According to reports from the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), carbapenemase-producing Enterobacteriaceae (CPE) are by far the most pressing antimicrobial resistance threat [ 70 ]. CPE has become a major global public health threat due to difficult-to-treat CPE bacterial infections in healthcare patients [ 71 ]. Enterobacteriaceae are a large family of Gram-negative bacteria that includes many bacteria commonly found as part of the normal human intestinal flora [ 72 ].…”

Section: Introductionmentioning

confidence: 99%

The Challenge of Overcoming Antibiotic Resistance in Carbapenem-Resistant Gram-Negative Bacteria: “Attack on Titan”

et al. 2023

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The global burden of bacterial resistance remains one of the most serious public health concerns. Infections caused by multidrug-resistant (MDR) bacteria in critically ill patients require immediate empirical treatment, which may not only be ineffective due to the resistance of MDR bacteria to multiple classes of antibiotics, but may also contribute to the selection and spread of antimicrobial resistance. Both the WHO and the ECDC consider carbapenem-resistant Enterobacteriaceae (CRE), carbapenem-resistant Pseudomonas aeruginosa (CRPA), and carbapenem-resistant Acinetobacter baumannii (CRAB) to be the highest priority. The ability to form biofilm and the acquisition of multiple drug resistance genes, in particular to carbapenems, have made these pathogens particularly difficult to treat. They are a growing cause of healthcare-associated infections and a significant threat to public health, associated with a high mortality rate. Moreover, co-colonization with these pathogens in critically ill patients was found to be a significant predictor for in-hospital mortality. Importantly, they have the potential to spread resistance using mobile genetic elements. Given the current situation, it is clear that finding new ways to combat antimicrobial resistance can no longer be delayed. The aim of this review was to evaluate the literature on how these pathogens contribute to the global burden of AMR. The review also highlights the importance of the rational use of antibiotics and the need to implement antimicrobial stewardship principles to prevent the transmission of drug-resistant organisms in healthcare settings. Finally, the review discusses the advantages and limitations of alternative therapies for the treatment of infections caused by these “titans” of antibiotic resistance.

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Section: Introductionmentioning

confidence: 99%