Microbial endophytes and their intellectual property rights

Rai, Anurag; Chandra, Avinash

doi:10.1016/b978-0-12-819654-0.00014-4

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Among actinomycetes, streptomycetes are the most active compound producers and have provided more than 7600 of the currently known compounds [10]. These compounds have demonstrated potential applicability in medicine, agriculture, and industry [11]. Actinomycetes are ubiquitous in most plants; however, most have been isolated from soil and marine environments and not from the inner plant tissues [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Bioprospecting of endophytic actinobacterium associated with Aloe ferox mill for antibacterial activity

Maliehe

Mbambo

Ngidi

et al. 2022

BMC Complement Med Ther

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Background The emergence of drug resistance among pathogens has resulted in renewed interest in bioprospecting for natural microbial products. Methods This study aimed to bioprospecting endophytic actinobacterium associated with Aloe ferox Mill for its antibacterial activity. Endophytic actinomycetes were isolated from the gel of A. ferox Mill by surface sterilization technique using actinomycete isolation agar. The isolate with a promising antibacterial activity was identified using 16S rRNA sequence analysis. The minimum inhibitory concentration (MIC) of the extract was assessed by the micro-dilution method and its effect on the respiratory chain dehydrogenase (RCD) activity was ascertained by the iodonitrotetrazolium chloride (INT) assay. Fourier transform-infrared spectrophotometer (FTIR) and gas chromatography-mass spectrophotometry (GC-MS) were employed to identify functional groups and the chemical constituents, respectively. Results The actinobacterium was found to be Streptomyces olivaceus CP016795.1. Its extract displayed noteworthy antibacterial activity (MIC ≤1 mg/mL) against Staphylococcus aureus (ATCC 25925), Bacillus cereus (ATCC 10102), and Escherichia coli (ATCC 25922); and showed an inhibitory effect on the RCD activity. FTIR spectrum displayed hydroxyl, amine, and aromatic groups, and the GC–MS revealed 5-Hydroxymethylfurfural as the main constituent (19.47%). Conclusions S. olivaceus CP016795.1 can serve as a potential source of effective antibacterial compounds.

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Section: Introductionmentioning

confidence: 99%

Bioprospecting of endophytic actinobacterium associated with Aloe ferox mill for antibacterial activity

Maliehe

Mbambo

Ngidi

et al. 2022

BMC Complement Med Ther

View full text Add to dashboard Cite

show abstract

“…These compounds have demonstrated potential applicability in medicine, agriculture, and industry [11].…”

Section: Introductionmentioning

confidence: 99%

Bioprospecting of endophytic actinobacterium associated with Aloe ferox Mill for antimicrobial activity

Maliehe

Mbambo

Ngidi

et al. 2022

Preprint

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Background: The emergence of drug resistance among pathogens has resulted in renewed interest in bioprospecting for natural microbial products. Methods: This study aimed to bioprospecting endophytic actinobacterium associated with Aloe ferox Mill for its antibacterial activity. Endophytic actinomycetes were isolated from the gel of A. ferox Mill by surface sterilization technique using actinomycete isolation agar. The isolate with a promising antibacterial activity was identified using 16S rRNA sequence analysis. The minimum inhibitory concentration (MIC) of the extract was assessed by the micro-dilution method and its effect on the respiratory chain dehydrogenase (RCD) activity was ascertained by the iodonitrotetrazolium chloride (INT) assay. Fourier transform-infrared spectrophotometer (FTIR) and gas chromatography-mass spectrophotometry (GC-MS) were employed to identify functional groups and the chemical constituents, respectively. Results: The actinobacterium was found to be Streptomyces olivaceus CP016795.1. Its extract displayed noteworthy antibacterial activity (MIC ≤ 1 mg/mL) against Staphylococcus aureus (ATCC 25925), Bacillus cereus (ATCC 10102), and Escherichia coli (ATCC 25922); and showed an inhibitory effect on the RCD activity. FTIR spectrum displayed hydroxyl, amine, and aromatic groups, and the GC–MS revealed 5-Hydroxymethylfurfural as the main constituent (19.47%). Conclusions: S. olivaceus CP016795.1 can serve as a potential source of effective antibacterial compounds.

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“…Now a day, worldwide approximately one quarter of the total drugs in total usage originated from plants. Two hundred and fifty-two basic and essential drugs were prescribed by the World Health Organization (WHO), 11% comes from plant or plant based derivatives [13], [14] . Plants served as an important resource of pharmaceutically active biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological perspectives and phytochemical reservoir of Withania somnifera: A review

Srivastava¹,

Upadhyay²,

Gupta³

2021

ijomrc

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Plants have always been an indispensable part of human life since the beginning of human civilisation. Withania somnifera (L.) DUNAL, popularly known as Wintercherry or Indian Ginseng, is widely considered as Ashwagandha. In Ayurveda, it is classified as a Rasayana (rejuvenation) and projected to promote mental and physical health, rejuvenate the body in debilitated conditions and increase longevity. Due to its beneficial chemical constituents, the herb possesses a broad spectrum of biological activities and is used to treat a variety of diseases affecting human health. These include Cardioprotective activity, Anti-cancer activity, Immunomodulatory activity, Neuroprotective activity, Antimicrobial activity, Anti-stress activity,Anti-diabetic activity and Anti-inflammatory activity. The present review discusses the pharmacological importance of Withania somnifera and its important constituents.

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Microbial endophytes and their intellectual property rights

Cited by 4 publications

References 31 publications

Bioprospecting of endophytic actinobacterium associated with Aloe ferox mill for antibacterial activity

Bioprospecting of endophytic actinobacterium associated with Aloe ferox mill for antibacterial activity

Bioprospecting of endophytic actinobacterium associated with Aloe ferox Mill for antimicrobial activity

Pharmacological perspectives and phytochemical reservoir of Withania somnifera: A review

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