As a reliable source for methane production, the major goal of our research was to design and testify a novel microbial electrolysis assisted upflow anaerobic (Upflow-MEC) reactor for beer wastewater treatment and simultaneous methane production.Three reactors with different cathode materials were constructed and the reactor with Ni cathode had a maximum COD removal of 85%, methane yield of 142.8 ml/gCOD, TOC removal of 83%, Carbohydrate removal of 97%, Protein removal of 62% and current production of 8.6 mA, under 0.8 V applied voltage at HRT of 24 h. It was an application-oriented, membrane-free, continuous reactor and shortening the reaction time and increasing organic content conversion to methane were the key developing targets.