Microbial detection in seroma fluid preceding the diagnosis of breast implant-associated anaplastic large cell lymphoma: a case report and review of the literature

Fricke, Alba; Wagner, Juri; Kricheldorff, Julian; Rancso, Christoph; Fritschen, Uwe von

doi:10.1080/23320885.2019.1593846

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…Serial punctures should be avoided as the diluting effect makes diagnosis more difficult. In addition, a bacterial examination should be performed 38 . Solid tumors are biopsied.…”

Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

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Breast Implant-Associated Tumors

Fritschen

Kremer

Prantl

et al. 2023

Geburtshilfe Frauenheilkd

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In addition to anaplastic large T-cell lymphomas (BIA-ALCL), other implant-related tumors have been described for some years. Squamous cell carcinoma (SSC) and B-cell lymphomas occurred in very rare cases. The unexplained pathogenesis as well as the unclear individual risk profile is an ongoing source of uncertainty for patients and physicians. The pathogenesis of the tumors is still largely not understood. While BIA-ALCL occurs more frequently with textured breast implants, other tumors were also observed with smooth implants and at other implant sites. Multiple potential mechanisms are discussed. It is suspected that the etiology of a chronic inflammatory response and subsequently immunostimulation is multifactorial and appears to play a key role in the malignant transformation. Since there are currently no sufficiently valid data for a specific risk assessment, this must be done with caution. This article presents the incidence, pathogenesis, as well as the level of evidence according to the current state of knowledge, and evaluates and discusses the current literature.

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“…Serial punctures should be avoided as the diluting effect makes diagnosis more difficult. In addition, a bacterial examination should be performed 38 . Solid tumors are biopsied.…”

Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

“…Serielle Punktionen sollen vermieden werden, da der Dilutionseffekt die Diagnostik erschwert. Zusätzlich sollte eine bakterielle Untersuchung erfolgen 38 . Solide Tumoren werden biopsiert.…”

Section: Klinik Und Diagnoseunclassified

Breast Implant-Associated Tumors

Fritschen

Kremer

Prantl

et al. 2023

Geburtshilfe Frauenheilkd

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“…2 Textured implants have the highest risk of developing BIA-ALCL. 3 The underlying pathophysiology of BIA-ALCL is poorly understood; however, immunological mechanisms involving T cells proliferation and the associated inflammation have been postulated. 4 BIA-ALCL can also complicate silicone implant granulomas, which originally form due to silicone-induced granulomatous reaction on the implant's capsule.…”

mentioning

confidence: 99%

“…The Food and Drug Administration first noted the association between breast implants and BIA-ALCL in 2011 2 . Textured implants have the highest risk of developing BIA-ALCL 3 . The underlying pathophysiology of BIA-ALCL is poorly understood; however, immunological mechanisms involving T cells proliferation and the associated inflammation have been postulated 4 .…”

mentioning

confidence: 99%

Relapsed Breast Implant–Associated Anaplastic Large-Cell Lymphoma Presenting as Refractory Fluid Collections With Low Uptake on FDG PET/CT Scan

Alsa'di

Donald

2021

Clin Nucl Med

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Breast implant–associated anaplastic large-cell lymphoma is a rare type of non-Hodgkin lymphoma that occurs years after placement of textured surface breast implants. Patients typically present after the development of pain, a palpable mass, or swelling. We present a case of a 45-year-old woman with recurrent breast implant–associated anaplastic large-cell lymphoma presenting as refractory fluid collections, and the unusual finding of low uptake on FDG PET/CT scan despite being confirmed by cytology.

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Brustimplantatassoziierte Tumoren

von Fritschen,

Kremer,

Prantl

et al. 2024

Senologie - Zeitschrift für Mammadiagnostik und -therapie

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ZusammenfassungZusätzlich zu dem anaplastischen großzelligen T-Zell-Lymphom (BIA-ALCL) werden seit einigen Jahren weitere Tumoren im Zusammenhang mit Implantaten beschrieben. Sehr selten traten Plattenepithelkarzinome (SSC) und B-Zell-Lymphome auf. Die ungeklärte Pathogenese sowie das unklare individuelle Risikoprofil bringen eine anhaltende Verunsicherung von Patienten und Ärzten mit sich. Während das BIA-ALCL gehäuft im Zusammenhang mit texturierten Brustimplantaten auftritt, wurden die anderen Tumoren auch bei glattwandiger Textur und anderen Implantatlokalisationen beobachtet. Multiple potenzielle Mechanismen werden diskutiert. Eine vermutlich multifaktorielle Genese, die zu einer chronischen Entzündungsreaktion mit konsekutiver Immunstimulation führt, scheint eine Schlüsselrolle bei der malignen Transformation zu spielen. Für eine spezifische Risikobewertung liegen bisher keine ausreichend validen Daten vor, weshalb diese zurückhaltend erfolgen muss. Dargestellt werden Inzidenz, Pathogenese und Evidenzlevel des aktuellen Wissensstands sowie eine Bewertung und Diskussion der aktuellen Literatur.

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Microbial detection in seroma fluid preceding the diagnosis of breast implant-associated anaplastic large cell lymphoma: a case report and review of the literature

Cited by 3 publications

References 20 publications

Breast Implant-Associated Tumors

Breast Implant-Associated Tumors

Relapsed Breast Implant–Associated Anaplastic Large-Cell Lymphoma Presenting as Refractory Fluid Collections With Low Uptake on FDG PET/CT Scan

Brustimplantatassoziierte Tumoren

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