“…Several of these by-products have been used as supports and/or substrates for production of metabolites of industrial interest, such as organic acids, antibiotics, pigments, flavor and aroma compounds, bioactive molecules and a great variety of enzymes (Martins et al, 2011). Biotechnology offers significant advantages, such as high concentration of metabolite obtained product stability and adaptability of microorganisms especially fungi system with low free Science Publications AJABS water content (Chen, 2013;Howard et al, 2003;Pandey, 2003;Pandey et al, 1999;Shah et al, 2005).…”