Microbial conversion of steroid compounds: recent developments

Mutation breeding of high 4-androstene-3,17-dione-producing Mycobacterium neoaurum ZADF-4 by atmospheric and room temperature plasma treatment

“…In recent years, with the increasing consumption of steroid drugs, the use of biotransformation in the production of steroid medicine intermediates has attracted more attention because it is highly efficient, safe, and environmentally friendly (Fernandes et al, 2003;Swizdor et al, 2012). The strain of ZAD stored in our lab could efficiently transform phytosterols to AD and ADD, the most important steroid intermediates.…”

Microbial Oxidation of Finasteride With Macrophomina Phaseolina(kucc 730)

“…Since then, steroidal drugs have emerged as the second largest category of drugs in the pharmaceutical industry with about 300 steroidal drugs in the market [8]. Many reports on microbial conversion of steroids have been published during the last half-century [9,6,[10][11][12][13][14][15][16][17][18][19][20][21] focusing mainly on steroidal dehydrogenation, hydroxylations, esterification, halogenations, isomerization, methoxylation, and side-chain cleavage [22,23]. In continuation of our work on microbiotransformation [24][25][26][27][28] for the first time, we report here the fermentation of finasteride (1) with Macrophomina phaseolina (ATCC730) in order to obtain further microbial derivatives of finasteride which can be future candidates of drugs.…”

Microwave-Assisted Three-Liquid-Phase Extraction of Diosgenin and Steroidal Saponins from Fermentation Broth of <i>Dioscorea zingiberensis</i> C. H. Wright

“…Diosgenin, an important starting material in the partial synthesis of steroid hormones, is generally obtained from the roots of plants of the genus Dioscorea [1,2]. Dioscorea zingiberensis C. H. Wright (DZW) is among the most important resources for diosgenin production.…”