Microbial conversion of steffimycin and steffimycin B to 10-dihydrosteffimycin and 10-dihydrosteffimycin B.

Streptomyces scabrisporus, an endophyte isolated from Amphipterygium adstringens as producer of an anthracycline active against different cancer cell lines

“…On the contrary, antifungal activity against fourteen human pathogenic fungi was not detected [34]. Studies to improve the activity and solubility of this molecule either via chemical, microbiological or molecular biology have also been performed by different groups [39][40][41]. Furthermore, isolation, characterization and heterologous expression of the StefB gene cluster, was also explored [42].…”