Microbial conversion of glycerol to 1,3-propanediol

Abstract

Glycerol produced by cleavage of natural fats can microbially be converted to 1,3-propanediol (PD) by Citrobacter, Klebsiella and Clostridia strains. The fermentation by C. butyricum, product recovery and purification has been investigated in detail up to the 2 m 3 scale. Estimation of product costs for a 10,000 t/a plant indicates that the microbial process is obviously more attractive than the chemical route. Presently, 1,3-propanediol has only a low market volume; however, its use for special polycondensates, in particular polyesters, could reduce glycerol surpluses and make plastics a easily biodegradable part of natural cycles.

Microbial Conversion of Glycerol to 1,3-Propanediol by an Engineered Strain of Escherichia coli

“…Acetate, formate, lactate, and succinate, in addition to being by-products of glucose fermentation, are known by-products of conversion of glycerol to 1,3-PD (25). High by-product concentrations have been shown to slow or inhibit the growth rate of recombinant cells, thereby negatively impacting 1,3-PD production (10). Therefore, we assayed for by-product production during the fermentative conversion of glycerol to 1,3-PD (Fig.…”

Experimental Design For 1,3-Propanediol Biosynthesis by K. Pneumoniae GLC29 Using Glycerol

“…However, new applications are being studied for large volumes of biodiesel glycerol, since it can't be used in food and cosmetics industries without a cleaning and refining process [7]. Glycerol may be used as carbon source in bioprocesses, and several species among the genera Clostridium, Citrobacter, Klebsiella and Pseudomonas [5,[7][8][9][10][11][12][13] are being studied for the biotransformation of glycerol from biodiesel to specialty chemicals. One promising solution is the use of biodiesel glycerol to produce 1,3-propanediol (1, by Klebsiella pneumoniae and Clostridium butyricum [14,15].…”

Síntesis, caracterización y aplicaciones biomédicas de redes de copolímeros basados en poliésteres.

“…Los monómeros utilizados generalmente en las reacciones de policondensación son derivados del petróleo [30], aunque, algunos son obtenidos a través de fuentes renovables. Por ejemplo, la producción de 1,3…”

“…propanodiol es a través de la fermentación del glicerol [30], la producción del ácido succínico mediante la fermentación de carbohidratos como la glucosa, sucrosa, maltosa o fructosa usando la bacteria Anaerobiospirillum succiniciproducens [31] y también a partir de la fermentación de la glucosa pero usando la bacteria gram-negativa Actinobacillus succinogenes a partir de la producción de succinatos [32].…”