Microbial Contamination of Hydrophilic Contact Lenses: Quantitation and Identification of Microorganisms Associated with Contact Lenses while on the Eye

Hart, Dean E.; Reindel, William; Proskin, Howard M.; Mowrey-McKee, Mary

doi:10.1097/00006324-199303000-00002

Cited by 42 publications

(27 citation statements)

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“…31 The source of bacteria (other than normal ocular microbiota) that colonize lenses is usually attributed to lens handling although it has been reported that the lens surface is almost clear of microorganisms immediately after a lens has been inserted. 13,20 Changes in the ocular microbiota can be influenced by EW of soft contact lenses 23 and microorganisms that colonize lens storage cases may also influence the ocular microbiota in lens wearers. 23 The participants in this study were not using care systems or storage cases.…”

Section: Discussionmentioning

confidence: 99%

“…11 Bacterial contamination of hydrogel contact lenses during asymptomatic wear may occur at a rate of approximately 50%, but this generally involves a small number of microorganisms. [12][13][14] Generally, coagulase negative staphylococci followed by S. aureus, streptococci and less frequently gram-negative bacteria are isolated from contact lenses or ocular surfaces after asymptomatic wear. [15][16][17][18] Contact lens contamination usually occurs by lens handling or as a result of contamination from the domestic water supply; 19 however, the contaminants appear to clear rapidly from the surface of the lens.…”

mentioning

confidence: 99%

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External Ocular Surface and Lens Microbiota in Contact Lens Wearers With Corneal Infiltrates During Extended Wear of Hydrogel Lenses

Willcox

Sharma

Naduvilath

et al. 2011

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

External Ocular Surface and Lens Microbiota in Contact Lens Wearers With Corneal Infiltrates During Extended Wear of Hydrogel Lenses

Willcox

Sharma

Naduvilath

et al. 2011

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…It is therefore obvious that there are controversies about the effect of soft contact lenses on ocular microbiota and the associated diseases. Many authors reported that asymptomatic lens wear for extended periods did increase ocular microbiota (Larkin et al, 1991;Hart et al, 1993) and others reported that asymptomatic lens worn for extended periods did not increase normal ocular microbiota (Gopinathan et al, 1997;Willcox et al, 1997). However, Efron et al (2005) suggested that ocular diseases of contact lens wearer could be as a result of noncompliance or omission of surfactant cleaning rub and rinse steps, the use of disinfecting solution of marginal efficacy and lenses that attract and rapidly deposit protein.…”

Section: Discussionmentioning

confidence: 99%

Bacteria isolated from contact and non contact lens and antibiotic susceptibility patterns of isolated Pseudomonas aeruginosa

Al-Zahrani¹

2012

Afr. J. Microbiol. Res.

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The aim of this study was to investigate the prevalence and type of microbial contamination, associated with contact lenses and lens care accessories used by a group of contact lens wearers. Results show that a total of 178 strains were isolated, including, 100 Gram positive and 78 Gram negative bacteria. Staphylococcus epidermidis and Pseudomonas aeruginosa were the most common microorganisms isolated (25.281 and 13.483% respectively. 24 P. aeruginosa were isolated from lenses and eyes of contact lens and non-contact lens wearers. All isolates were susceptible to the tested aminoglycosides and fluoroquinolones. Aminoglycosides and fluoroquinolones (ciprofloxacin) were more efficient than β-lactams. 91.67% of the strains had intermediate-resistant to cefotaximee; 4.17% were resistant and 4.17% were sensitive to Cefotaximee. 95.83% of the strains were sensitive, while 4.17% were resistant to Imipenem. 20.83 and 12.5% of P. aeruginosa strains were resistant and sensitive to Ceftriaxone respectively, while 66.67% were moderately-resistant to ceftriaxone of the β-lactam class. All isolates were sensitive to the other tested β-lactam.

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“…Approximately half of all patient worn soft lenses are predominantly colonized by normal lid or skin flora including CNS, Propionibacterium, Corynebacterium, Micrococcus , and Bacillus sp and S. epidermidis is the most frequently isolated staphylococcal species. 19,29,35 Leitch et al 36 identified and enumerated all the Staphylococci found on traditional hydrophilic lenses on repeated occasions over 1 year in 97 patients. Approximately half (48.8%) of all lenses harbored some Staphylococci in agreement with other groups.…”

Section: Bioburdenmentioning

confidence: 99%

Microbial Contamination of Contact Lenses, Lens Care Solutions, and Their Accessories: A Literature Review

Szczotka-Flynn

Pearlman

Ghannoum

2010

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

207

155

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Purpose A contact lens (CL) can act as a vector for microorganisms to adhere to and transfer to the ocular surface. Commensal microorganisms that uneventfully cohabitate on lid margins and conjunctivae and potential pathogens that are found transiently on the ocular surface can inoculate CLs in vivo. In the presence of reduced tissue resistance, these resident microorganisms or transient pathogens can invade and colonize the cornea or conjunctiva to produce inflammation or infection. Methods The literature was reviewed and used to summarize the findings over the last 30 years on the identification, enumeration, and classification of microorganisms adherent to CLs and their accessories during the course of normal wear and to hypothesize the role that these microorganisms play in CL infection and inflammation. Results Lens handling greatly increases the incidence of lens contamination, and the ocular surface has a tremendous ability to destroy organisms. However, even when removed aseptically from the eye, more than half of lenses are found to harbor microorganisms, almost exclusively bacteria. Coagulase-negative Staphylococci are most commonly cultured from worn lenses; however, approximately 10% of lenses harbor Gram-negative and highly pathogenic species, even in asymptomatic subjects. In storage cases, the incidence of positive microbial bioburden is also typically greater than 50%. All types of care solutions can become contaminated, including up to 30% of preserved products. Conclusions The process of CL-related microbial keratitis and inflammation is thought to be preceded by the presence or transfer or both of microorganisms from the lens to the ocular surface. Thus, this detailed understanding of lens-related bioburden is important in the understanding of factors associated with infectious and inflammatory complications. Promising mechanisms to prevent bacterial colonization on lenses and lens cases are forthcoming, which may decrease the incidence of microbially driven CL complications.

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Microbial Contamination of Hydrophilic Contact Lenses: Quantitation and Identification of Microorganisms Associated with Contact Lenses while on the Eye

Cited by 42 publications

References 0 publications

External Ocular Surface and Lens Microbiota in Contact Lens Wearers With Corneal Infiltrates During Extended Wear of Hydrogel Lenses

External Ocular Surface and Lens Microbiota in Contact Lens Wearers With Corneal Infiltrates During Extended Wear of Hydrogel Lenses

Bacteria isolated from contact and non contact lens and antibiotic susceptibility patterns of isolated Pseudomonas aeruginosa

Microbial Contamination of Contact Lenses, Lens Care Solutions, and Their Accessories: A Literature Review

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