Microbial cell factory optimisation using genome-wide host-pathway interaction screens
Paul Cachera,
Nikolaj Can Kurt,
Andreas Røpke
et al.
Abstract:The ubiquity of genetic interactions in living cells challenges the concept of parts orthogonality, which is a cornerstone of synthetic biology. Parts, such as heterologously expressed genes, draw from shared pools of limited cellular resources and interactions between parts themselves and their host are inevitable. Instead of trying to eliminate or disregard these interactions, we propose to leverage them to promote desirable phenotypes. We recently described CRI-SPA, a method for high-throughput genome-wide … Show more
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