Microbial biotransformation of some novel hydantoin derivatives: Perspectives for bioremediation of potential sunscreen agents

Popiół, Justyna; Piska, Kamil; Słoczyńska, Karolina; Bień, Anna; Żelaszczyk, Dorota; Gunia‐Krzyżak, Agnieszka; Koczurkiewicz, Paulina; Wójcik-Pszczoła, Katarzyna; Marona, Henryk; Pękala, Elżbieta

doi:10.1016/j.chemosphere.2019.05.254

Cited by 6 publications

(4 citation statements)

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“…The optical density data of converted dye was measured at 570 nm (A570) on microplate reader. Viability (percent of control) was determined by dividing A570 of experimental wells by A570 of control wells × 100% [ 15 , 77 ]. The experiment was conducted two times with three repetitions for each condition.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…These molecules were photostable, exhibited no estrogenic activity in the MCF-7 breast cancer model, no cytotoxicity in selected human skin cells, and were nonmutagenic in the Ames test [14]. Moreover, their metabolic fate with the environmental fungus Cunninghamella echinulata was evaluated [15]. Furthermore, due to their release into the aquatic environment, UV filters and their metabolites are considered an important group of emerging contaminants [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…These molecules were photostable, exhibited no estrogenic activity in the MCF-7 breast cancer model, no cytotoxicity in selected human skin cells, and were nonmutagenic in the Ames test [14]. Moreover, their metabolic fate with the environmental fungus Cunninghamella echinulata was evaluated [15]. As a continuation of our ongoing studies, we have conducted several in vitro tests to assess the new UV filter candidates JH3 and JH10 using the reconstructed human skin model Episkin TM .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Two Novel Hydantoin Derivatives Using Reconstructed Human Skin Model EpiskinTM: Perspectives for Application as Potential Sunscreen Agents

et al. 2022

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This study aimed to assess two novel 5-arylideneimidazolidine-2,4-dione (hydantoin) derivatives (JH3 and JH10) demonstrating photoprotective activity using the reconstructed human skin model EpiskinTM. The skin permeability, irritation, and phototoxicity of the compounds was evaluated in vitro. Moreover, the in vitro genotoxicity and human metabolism of both compounds was studied. For skin permeation and irritation experiments, the test compounds were incorporated into a formulation. It was shown that JH3 and JH10 display no skin irritation and no phototoxicity. Both compounds did not markedly enhance the frequency of micronuclei in CHO-K1 cells in the micronucleus assay. Preliminary in vitro studies with liver microsomes demonstrated that hydrolysis appears to constitute their important metabolic pathway. EpiskinTM permeability experiments showed that JH3 permeability was lower than or close to currently used UV filters, whereas JH10 had the potential to permeate the skin. Therefore, a restriction of this compound permeability should be obtained by choosing the right vehicle or by optimizing it, which should be addressed in future studies.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…These molecules were photostable, exhibited no estrogenic activity in the MCF-7 breast cancer model, no cytotoxicity in selected human skin cells, and were nonmutagenic in the Ames test [14]. Moreover, their metabolic fate with the environmental fungus Cunninghamella echinulata was evaluated [15]. As a continuation of our ongoing studies, we have conducted several in vitro tests to assess the new UV filter candidates JH3 and JH10 using the reconstructed human skin model Episkin TM .…”

Section: Introductionmentioning

confidence: 99%

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