Microbial biotechnology

Antwis, Rachael E.; Fry, Ellen L.; James, Chloë E.; Ferry, Nicolas

doi:10.1017/9781108654418.009

Cited by 2 publications

(2 citation statements)

References 236 publications

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“…All complex organisms carry numerous microbes forming diverse microbial communities in many organs including the skin, lungs, and gut (Antwis, Fry, James, & Ferry, 2020;Müller, Vogel, Bai, & Vorholt, 2016;Zilber-Rosenberg & Rosenberg, 2008). These microbial communities contribute to the function of these organs: millions of years of intimate interactions between the host and its microbiome have forged pervasive interconnections between both parties.…”

Section: Introductionmentioning

confidence: 99%

Association between the skin microbiome and MHC class II diversity in an amphibian

Cortázar-Chinarro

Richter‐Boix

Rödin‐Mörch

et al. 2023

Preprint

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It has become clear that the microbiome plays an important role in determining host health, diseases, and phenotypic variation. There is increasing evidence that the microbiome influences host fitness and its adaptation to the environment is changing our thinking on host-microbe interactions. However, it remains unclear how a host genotype shapes its microbiome. Here, we explored how genetic background and evolutionary history influence associated microbiome in amphibian populations. We studied how skin bacterial diversity is associated with the Major Histocompatibility Complex (MHC) class II exon 2 diversity in 12 moor frog populations belonging to two geographical clusters that show signatures of past and ongoing differential selection patterns. We found that bacterial alpha-diversity remained similar between the two clusters, while MHC haplotype-supertypes and genetic diversity differed between the clusters. Bacterial alpha-diversity was positively correlated with expected MHC heterozygosity and negatively with MHC nucleotide diversity. We also found that bacterial community composition differed significantly between the two geographic clusters and between specific MHC supertypes. These findings further suggest that population historical demographic events influence hologenomic variation and provide new insights into how immunogenetic host variability and microbial diversity may jointly influence host fitness with consequences for disease susceptibility and population persistence.

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Section: Introductionmentioning

confidence: 99%

Association between the skin microbiome and MHC class II diversity in an amphibian

Cortázar-Chinarro

Richter‐Boix

Rödin‐Mörch

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…All multicellular organisms host microbes. These form diverse communities that associate with a host's organs, such as the skin, lungs and gut (Antwis et al., 2020; Müller et al., 2016; Zilber‐Rosenberg & Rosenberg, 2008). These microbial communities contribute to the functioning of the associated organs because of tight interconnections shaped by long co‐evolutionary history between a host and its microbiome have forged pervasive interconnections between both parties.…”

Section: Introductionmentioning

confidence: 99%

Association between the skin microbiome and MHC class II diversity in an amphibian

Cortazar‐Chinarro,

Richter‐Boix,

Rödin‐Mörch

et al. 2023

Molecular Ecology

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Microbiomes play an important role in determining the ecology and behaviour of their hosts. However, questions remain pertaining to how host genetics shape microbiomes, and how microbiome composition influences host fitness. We explored the effects of geography, evolutionary history and host genetics on the skin microbiome diversity and structure in a widespread amphibian. More specifically, we examined the association between bacterial diversity and composition and the major histocompatibility complex class II exon 2 diversity in 12 moor frog (Rana arvalis) populations belonging to two geographical clusters that show signatures of past and ongoing differential selection. We found that while bacterial alpha diversity did not differ between the two clusters, MHC alleles/supertypes and genetic diversity varied considerably depending on geography and evolutionary history. Bacterial alpha diversity was positively correlated with expected MHC heterozygosity and negatively with MHC nucleotide diversity. Furthermore, bacterial community composition showed significant variation between the two geographical clusters and between specific MHC alleles/supertypes. Our findings emphasize the importance of historical demographic events on hologenomic variation and provide new insights into how immunogenetic host variability and microbial diversity may jointly influence host fitness with consequences for disease susceptibility and population persistence.

show abstract

Microbial biotechnology

Cited by 2 publications

References 236 publications

Association between the skin microbiome and MHC class II diversity in an amphibian

Association between the skin microbiome and MHC class II diversity in an amphibian

Association between the skin microbiome and MHC class II diversity in an amphibian

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