Microbial Biofilms

Maddela, Naga Raju; Abiodun, Aransiola Sesan

doi:10.1201/9781003184942

Cited by 3 publications

(2 citation statements)

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“…[24] They additionally demonstrated encouraging invitro antioxidant activity. [25] A few hydrazides were also created and tested for their potency against cancer, which showed high activity. [22,26] On the other hand, pyridines are also one of the bioactive heterocycles that attracted the interest of medicinal and organic chemists due to their potent biological and medicinal properties.…”

Section: Introductionmentioning

confidence: 99%

“…Hydrazide derivatives are a class of heterocyclic organic compounds that has been shown to have potent anti‐Herpes simplex type‐1 (HSV‐1) activities [24] . They additionally demonstrated encouraging in‐vitro antioxidant activity [25] . A few hydrazides were also created and tested for their potency against cancer, which showed high activity [22,26]…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, Bioactivity Screening and Computational Studies of Diphenyl−malonohydrazides and Pyridines Derivatives

et al. 2023

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A series of new hydrazide (3 a-j) and pyridine (11 a-j) derivatives were synthesized using a convergent synthetic methodology by condensation of malono-di(2-phenylhydrazide) with arylidene malononitrile or arylidene ethyl cyanoacetate derivatives. The synthesized compounds (3, 11 a-j) were characterized using via IR, 1 H-, 13 C-NMR, and MS spectroscopies as well as elemental analysis. The biological activity of these molecules has been evaluated in vitro against two grampositive bacteria (Staphylococcus aureus and Streptococcus pneumoniae) and one-gram negative bacteria (Escherichia coli), as well as one fungus (Candida albicans). The results of the bioactive assay revealed that the synthesized pyridine (11 a-j) derivatives had greater antibacterial efficacy than the hydrazide (3 a-j) derivatives and were comparable to the reference drug Augmentin. Furthermore, docking studies against the Staphylococcus aureus dihydrofolate reductase (DHFR) protein revealed that pyridine derivatives (11 a-j) had higher binding interactions affinity (ΔG = À 9.59 ∼ À 7.69 kcal/mol) than diphenylÀ malonohydrazide derivatives (3 a-j), which achieved a binding affinity in the range of (ΔG = À 9.65 ∼ À 6.77 kcal/ mol), supporting the experimental results. Finally, DFT and TD-DFT were used to gain a better understanding of the structureactivity relationship and biological activity of the new synthesized hydrazide/pyridine derivatives.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Bioactivity Screening and Computational Studies of Diphenyl−malonohydrazides and Pyridines Derivatives

et al. 2023

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Whey: As a Low-Cost Substrate for the Production of Biosurfactants

Chaudhary,

Kajla,

Luthra

et al. 2023

Whey Valorization

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Green Synthesized Silver Nanoparticles: A Novel Approach for the Enhanced Growth and Yield of Tomato against Early Blight Disease

et al. 2023

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Tomato plants are among the most widely cultivated and economically important crops worldwide. Farmers’ major challenge when growing tomatoes is early blight disease caused by Alternaria solani, which results in significant yield losses. Silver nanoparticles (AgNPs) have gained popularity recently due to their potential antifungal activity. The present study investigated the potential of green synthesized silver nanoparticles (AgNPs) for enhancing the growth and yield of tomato plants and their resistance against early blight disease. AgNPs were synthesized using leaf extract of the neem tree. Tomato plants treated with AgNPs showed a significant increase in plant height (30%), number of leaves, fresh weight (45%), and dry weight (40%) compared to the control plants. Moreover, the AgNP–treated plants exhibited a significant reduction in disease severity index (DSI) (73%) and disease incidence (DI) (69%) compared to the control plants. Tomato plants treated with 5 and 10 ppm AgNPs reached their maximum levels of photosynthetic pigments and increased the accumulation of certain secondary metabolites compared to the control group. AgNP treatment improved stress tolerance in tomato plants as indicated by higher activities of antioxidant enzymes such as PO (60%), PPO (65%), PAL (65.5%), SOD (65.3%), CAT (53.8%), and APX (73%). These results suggest that using green synthesized AgNPs is a promising approach for enhancing the growth and yield of tomato plants and protecting them against early blight disease. Overall, the findings demonstrate the potential of nanotechnology-based solutions for sustainable agriculture and food security.

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Microbial Biofilms

Cited by 3 publications

References 0 publications

Synthesis, Characterization, Bioactivity Screening and Computational Studies of Diphenyl−malonohydrazides and Pyridines Derivatives

Synthesis, Characterization, Bioactivity Screening and Computational Studies of Diphenyl−malonohydrazides and Pyridines Derivatives

Whey: As a Low-Cost Substrate for the Production of Biosurfactants

Green Synthesized Silver Nanoparticles: A Novel Approach for the Enhanced Growth and Yield of Tomato against Early Blight Disease

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