Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease

Gholizadeh, Pourya; Mahallei, Majid; Pormohammad, Ali; Varshochi, Mojtaba; Ganbarov, Khudaverdi; Zeinalzadeh, Elham; Yousefi, Bahman; Bastami, Milad; Tanomand, Asghar; Mahmood, Suhad Saad; Yousefi, Mehdi; Asgharzadeh, Mohammad; Kafil, Hossein Samadi

doi:10.1016/j.micpath.2018.11.031

Cited by 88 publications

(53 citation statements)

References 130 publications

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“…8 Some E. coli strains, however, have developed the ability to cause disease in the gastrointestinal, urinary, and central nervous systems. 9,10 Prolonged exposure of E. coli to antibiotics contributes to the development of antibiotic resistance. 11,12 Thus, antibiotic-resistant bacteria, including E. coli, in animals could serve as important reservoirs for colonization and infection in human beings.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of antibiotic resistance in Escherichia coli strains simultaneously isolated from humans, animals, food, and the environment: a systematic review and meta-analysis

Pormohammad

Nasiri

Azimi

2019

IDR

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149

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Background: Antimicrobial resistance is a serious public health problem worldwide. We aimed to investigate the prevalence of antibiotic resistance in Escherichia coli strains simultaneously isolated from humans, animals, food, and the environment. Methods: Studies on PubMed, Embase, and the Cochrane Library published from January 1, 2000 to January 1, 2018 were searched. The quality of the included studies was assessed by the modified critical appraisal checklist recommended by the Joanna Briggs Institute. All analyses were conducted using Biostat's Comprehensive Meta-Analysis version 2.0. Depending on the heterogeneity test for each antibiotic, we used a random-or fixedeffect model for pooled prevalence of drug resistance. Studies were eligible if they had investigated and reported resistance in two or more isolation sources (human, animal, food, or environment). To decrease heterogeneity and bias, we excluded studies that had reported E. coli drug resistance isolated from one source only. We included publications that reported drug resistance with minimum inhibitory concentration or disk diffusion method (DDM) as antibiotic-susceptibility tests. Results: Of the 39 included studies, 20 used the DDM and 19 minimum inhibitory concentration for their antibiotic-susceptibility testing. Colistin had the lowest prevalence, with 0.8% (95% CI 0.2%-3.8%) and amoxicillin the highest, with 70.5% (95% CI 57.5%-81%) in isolated human E. coli strains tested with the DDM. To assess historical changes in antimicrobial drug resistance, subgroup analysis from 2000 to 2018 showed a significant increase in ciprofloxacin resistance. Conclusion: Monitoring and evaluating antibiotic-sensitivity patterns and preparation of reliable antibiotic strategies may lead to better outcomes for inhibition and control of E. coli infections in different regions of the world.

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Section: Introductionmentioning

confidence: 99%

Prevalence of antibiotic resistance in Escherichia coli strains simultaneously isolated from humans, animals, food, and the environment: a systematic review and meta-analysis

Pormohammad

Nasiri

Azimi

2019

IDR

Self Cite

149

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“…Intestinal microbiota is recently referred as a "hidden organ," including a wide range of bacteria, with an extension of a gene pool much more abundant than that from the host. Intestinal microbiota and perturbations in the composition of the microbiota support numerous nutritional, metabolic, immunological, and physiological processes [8][9][10][11]. Amit-Romach et al [12] found that VAD diets alter the composition of intestinal microflora by decreasing the relative proportion of lactobacillus spp.…”

Section: Introductionmentioning

confidence: 99%

Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency

Zhou

Tang

et al. 2020

Journal of Diabetes Research

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Aims. The underlying mechanisms involved in Vitamin A- (VA-) related changes in glucose metabolic disorders remain unclear. Recent evidence suggests that intestinal microbiota is closely linked to the metabolic syndrome. Here, we explored whether and how intestinal microbiota affects glucose homeostasis in VA-deficient diet-fed mice. Methods. Six-week-old male C57BL/6 mice were randomly placed on either a VA-sufficient (VAS) or VA-deficient (VAD) diet for 10 weeks. Subsequently, a subclass of the VAD diet-fed mice was switched to a VA-deficient rescued (VADR) diet for an additional 8 weeks. The glucose metabolic phenotypes of the mice were assessed using glucose tolerance tests and immunohistochemistry staining. Changes in intestinal microbiota were assessed using 16S gene sequencing. The intestinal morphology, intestinal permeability, and inflammatory response activation signaling pathway were assessed using histological staining, western blots, quantitative-PCR, and enzyme-linked immunosorbent assays. Results. VAD diet-fed mice displayed reduction of tissue VA levels, increased area under the curve (AUC) of glucose challenge, reduced glucose-stimulated insulin secretion, and loss of β cell mass. Redundancy analysis showed intestinal microbiota diversity was significantly associated with AUC of glucose challenge and β cell mass. VAD diet-driven changes in intestinal microbiota followed the inflammatory response with increased intestinal permeability and higher mRNA expression of intestinal inflammatory cytokines through nuclear factor-κB signaling pathway activation. Reintroduction of dietary VA to VAD diet-fed mice restored tissue VA levels, endocrine hormone profiles, and inflammatory response, which are similar to those observed following VAS-controlled changes in intestinal microbiota. Conclusions. We found intestinal microbiota effect islet function via controlling intestinal inflammatory phenotype in VAD diet-fed mice. Intestinal microbiota influences could be considered as an additional mechanism for the effect of endocrine function in a VAD diet-driven mouse model.

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“…Plenty of research has demonstrated the indispensable role of microbiota in regulating host immunity, and the high diversity of gut microbiota has been shown to be critical for maintaining immune homeostasis and suppressing food allergy (Gholizadeh et al, 2019). More specifically, several recent studies have shown that particular bacterial strain in the microbiota mediated the function of some immune modulators (Furusawa et al, 2013;Turnbaugh et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The intestinal microbiota has been demonstrated to be tightly involved in food allergy processing and therefore is a promising therapeutic target (Ho & Bunyavanich, 2018;Marrs & Sim, 2018). The disorder of the whole microbiota structure has been connected with the occurrence of several diseases such as diabetes, obesity and allergy (Gholizadeh et al, 2019). Moreover, particular commensal bacterial strains have been demonstrated to be required for the suppression or exacerbation of specific diseases.…”

Section: Introductionmentioning

confidence: 99%

Butyricicoccus plays a key role in mediating the antagonism between probiotic and antibiotic on food allergy

Wang

Huang

et al. 2019

Food and Agricultural Immunology

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Food allergy is a severe food safety problem worldwide. Probiotics are effective in alleviating food allergy whereas antibiotics may exacerbate allergenic responses, but the knowledge on the interplay between them during food allergy is limited. In the present study, we investigate the activity of probiotic strain Lactobacillus casei (Lc) and antibiotic cocktail (Abx) on in a food allergy mouse model. The results showed that Lc relieved allergenic symptom and changed allergen-specific antibodies isotypes. Moreover, Lc upregulated chemokines in the spleen, and promoted regulatory CD103+ DC and IgA-producing B cell proliferation. In contrast, the application of Abx eliminated all these beneficial effects of Lc. Microbiota analysis revealed that the commensal genus Butyricicoccus was a critical mediator in the process. These results revealed the mechanisms of Lc and Abx interaction on food allergy and provided Butyricicoccus as a potential therapeutic target for food allergy.

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Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease

Cited by 88 publications

References 130 publications

<p>Prevalence of antibiotic resistance in <em>Escherichia coli</em> strains simultaneously isolated from humans, animals, food, and the environment: a systematic review and meta-analysis</p>

<p>Prevalence of antibiotic resistance in <em>Escherichia coli</em> strains simultaneously isolated from humans, animals, food, and the environment: a systematic review and meta-analysis</p>

Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency

Butyricicoccus plays a key role in mediating the antagonism between probiotic and antibiotic on food allergy

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