Microbial Associations with Pancreatic Cancer: A New Frontier in Biomarkers

Stasiewicz, Mark; Kwaśniewski, Marek; Karpiński, Tomasz M.

doi:10.3390/cancers13153784

Cited by 21 publications

(13 citation statements)

References 96 publications

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“…The gut virome, according to the recently established gut virome database, mainly consists of bacteriophages (97.7%), eukaryotic viruses (2.1%), and archaeal viruses (0.1%) [ 126 , 127 ]. De novo research is starting to shed light on the role of these organisms as a normal part of the microbiota, as well as their involvement in pathologies of the gastrointestinal system [ 128 ].…”

Section: Gut Microbiota: Fungal and Viral Changesmentioning

confidence: 99%

Trust Your Gut: The Association of Gut Microbiota and Liver Disease

et al. 2022

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The gut microbiota composition is important for nutrient metabolism, mucosal barrier function, immunomodulation, and defense against pathogens. Alterations in the gut microbiome can disturb the gut ecosystem. These changes may lead to the loss of beneficial bacteria or an increase in potentially pathogenic bacteria. Furthermore, these have been shown to contribute to the pathophysiology of gastrointestinal and extra-intestinal diseases. Pathologies of the liver, such as non-alcoholic liver disease, alcoholic liver disease, cirrhosis, hepatocellular carcinoma, autoimmune hepatitis, viral hepatitis, and primary sclerosing cholangitis have all been linked to changes in the gut microbiome composition. There is substantial evidence that links gut dysbiosis to the progression and complications of these pathologies. This review article aimed to describe the changes seen in the gut microbiome in liver diseases and the association between gut dysbiosis and liver disease, and finally, explore treatment options that may improve gut dysbiosis in patients with liver disease.

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Section: Gut Microbiota: Fungal and Viral Changesmentioning

confidence: 99%

Trust Your Gut: The Association of Gut Microbiota and Liver Disease

et al. 2022

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“…It may be that the faecal, oral and duodenal microbiomes may not represent ideal biomarkers for pancreatic cancer. Further, they may not be specific enough as similar patterns across oral, gut, and intratumour microbiomes may be observed in many different tumour types ( Kabwe et al., 2021a ; Stasiewicz et al., 2021 ). As such, screening of the oral, duodenal or faecal microbiomes may not provide an accurate and specific diagnostic tool for pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

The Microbiome in Pancreatic Cancer-Implications for Diagnosis and Precision Bacteriophage Therapy for This Low Survival Disease

Kabwe

Dashper

Tucci

2022

Front. Cell. Infect. Microbiol.

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While the mortality rates for many cancers have decreased due to improved detection and treatments, that of pancreatic cancer remains stubbornly high. The microbiome is an important factor in the progression of many cancers. Greater understanding of the microbiome in pancreatic cancer patients, as well as its manipulation, may assist in diagnosis and treatment of this disease. In this report we reviewed studies that compared microbiome changes in pancreatic cancer patients and non-cancer patients. We then identified which bacterial genera were most increased in relative abundance across the oral, pancreatic, duodenal, and faecal tissue microbiomes. In light of these findings, we discuss the potential for utilising these bacteria as diagnostic biomarkers, as well as their potential control using precision targeting with bacteriophages, in instances where a causal oncogenic link is made.

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“…In addition, Fusobacterium species were found to be associated with increased colon cancer risk, and Streptococcus species were suggested to be in uential in the development of lung cancer [33,34]. Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans have also been identi ed as correlative species with an increased risk of pancreatic cancer [35]. There have been substantial reports on the correlation between speci c oral microbiota and head and neck cancer [36].…”

Section: Discussionmentioning

confidence: 99%

Associations Between Missing Teeth and The Risk of Cancer in Korea: A Nationwide Cohort Study

Kang

Moon

Lee

et al. 2022

Preprint

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Background Poor dental health is correlated with an increased risk of cancer. Using a nationwide population cohort database, we investigated which cancer is highly associated with poor dental health and which dental indicator mostly influences cancer risk. Methods This study was conducted using the National Health Checkups (NHC) and National Health Insurance System (NHIS) database in Korea. NHC in Korea includes dental examinations. We retrieved subjects who underwent NHC between 2002 and 2003 and their medical information in NHIS database was followed until December 31,2015. Results Data for 200,170 who participated in the NHC between 2002 and 2003 were analysed. During the maximum follow-up period of 13 years, 15,506 (7.75%) subjects were diagnosed with cancer. The median time to cancer diagnosis after the dental examination was 87 months (range, 51–119 months). The proportion of people with missing teeth was higher in the cancer-diagnosed group than in the non-diagnosed group (26.27% vs. 22.59%, p<0.001). Among several dental health factors, missing teeth were significantly associated with higher cancer risk. Subjects with missing teeth showed a 12% increased cancer risk compared to those without missing teeth (odds ratio [OR] 1.12, 95% confidence interval [CI], 1.08–1.16). The risk was significantly higher, especially in lung, head and neck, pancreatic, liver, biliary, and esophageal cancers (OR 1.27 [95% CI, 1.14–1.41], 1.32 [95% CI, 1.13–1.55], 1.27 [95% CI, 1.02–1.58], 1.24 [95% CI, 1.1–1.4], 1.28 [95% CI, 1.03–1.6], 1.4 [95% CI, 1.04–1.88], respectively). Conclusions Missing teeth were the most important dental indicator associated with cancer risk. Korean adults with missing teeth should be cautious about the risk of severalcancers, particularly head and neck, lung, gastrointestinal, hepatobiliary, and pancreatic cancer.

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Microbial Associations with Pancreatic Cancer: A New Frontier in Biomarkers

Cited by 21 publications

References 96 publications

Trust Your Gut: The Association of Gut Microbiota and Liver Disease

Trust Your Gut: The Association of Gut Microbiota and Liver Disease

The Microbiome in Pancreatic Cancer-Implications for Diagnosis and Precision Bacteriophage Therapy for This Low Survival Disease

Associations Between Missing Teeth and The Risk of Cancer in Korea: A Nationwide Cohort Study

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