“…The data above shows that syphilis, which is considered the easiest to control among STIs, is still experiencing an increase and decrease in incidence, and this is possibly due to the influence of socio-cultural factors. Syphilis can generally be divided into two, namely, congenital syphilis (transmitted from mother to fetus during the womb) and acquired syphilis (transmitted through sexual intercourse or needles and contaminated blood products) [14]. Acquired syphilis is divided based on clinical manifestations, namely: a) Primary stage: ulcer/wound/ulcer, usually solitary, painless, firm borders, induration with enlarged regional lymph nodes (lymphadenopathy), usually lasting up to 3 weeks; b) Secondary stage: polymorphic red spots usually on the palms of the hands and soles of the feet, papulosquamous skin and mucosal lesions, fever, malaise, generalized lymphadenopathy, condyloma lata, patchy alopecia, meningitis, uveitis, retinitis, usually lasting 2-12 weeks.…”