Microbes and mental health: Can the microbiome help explain clinical heterogeneity in psychiatry?

Hayes, Christina L.; Peters, Brett J.; Foster, Jane A.

doi:10.1016/j.yfrne.2020.100849

Cited by 16 publications

(11 citation statements)

References 132 publications

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“…The complex and heterogenous nature of a mental disorder with multiple plausible etiopathologies certainly imposes challenges from both scientific and clinical perspectives. The heterogeneity observed in mental disorders could possibly be attributed to the diverse and highly individualized microbial patterns across the human population [43]. The dynamic nature of the human microbiota profile which evolves across an individual's life span due to various environmental and biological factors evokes questions pertaining to the potential of probiotics to offset such influences in exerting its long-term benefits [44].…”

Section: Discussionmentioning

confidence: 99%

“…The basic understanding of the anti-depressive mechanism of probiotics has been largely gathered from animal studies [36][37][38][39][40][41][42]. Although research outcomes generally favor the utilization of probiotics in the treatment of depression, there are gaps when it comes to translating preclinical studies to human studies, due to the heterogenous nature of de-pressive disorder and the dynamicity of individual microbes [43,44]. Nevertheless, the exploration of MGBA in depressive disorder has certainly laid the foundation for the expansion of a clinical approach in the management of this debilitating disorder utilizing probiotics, despite the shortcomings, as this is an emerging, yet a rapidly growing field of research [23,43,45].…”

Section: Introductionmentioning

confidence: 99%

“…Although research outcomes generally favor the utilization of probiotics in the treatment of depression, there are gaps when it comes to translating preclinical studies to human studies, due to the heterogenous nature of de-pressive disorder and the dynamicity of individual microbes [43,44]. Nevertheless, the exploration of MGBA in depressive disorder has certainly laid the foundation for the expansion of a clinical approach in the management of this debilitating disorder utilizing probiotics, despite the shortcomings, as this is an emerging, yet a rapidly growing field of research [23,43,45]. Therefore, we recognize the importance of understanding the basic mechanism of probiotics by specifically relating this to the possible etiopathologies of depression.…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder

et al. 2021

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The field of probiotic has been exponentially expanding over the recent decades with a more therapeutic-centered research. Probiotics mediated microbiota modulation within the microbiota–gut–brain axis (MGBA) have been proven to be beneficial in various health domains through pre-clinical and clinical studies. In the context of mental health, although probiotic research is still in its infancy stage, the promising role and potential of probiotics in various mental disorders demonstrated via in-vivo and in-vitro studies have laid a strong foundation for translating preclinical models to humans. The exploration of the therapeutic role and potential of probiotics in major depressive disorder (MDD) is an extremely noteworthy field of research. The possible etio-pathological mechanisms of depression involving inflammation, neurotransmitters, the hypothalamic–pituitary–adrenal (HPA) axis and epigenetic mechanisms potentially benefit from probiotic intervention. Probiotics, both as an adjunct to antidepressants or a stand-alone intervention, have a beneficial role and potential in mitigating anti-depressive effects, and confers some advantages compared to conventional treatments of depression using anti-depressants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder

et al. 2021

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“…Abbreviations: OB olfactory bulb, PVN paraventricular nucleus, VTA ventral tegmental area, NAc nucleus accumbens, NTS nucleus tractus solitarii, AMYG amygdala Furthermore, in this study the authors observed that antibiotic treatments blocked mating preference, suggesting that these commensal bacteria are able to alter mating behaviour by modifying pheromone levels. Sexual dimorphism in the gut microbiota may play an important role in modulating the gut-brain signalling and the reward system (Audet, 2019;Hayes et al, 2020;Jaggar et al, 2020).…”

Section: Maternal Care Social Play and Sexual Behaviourmentioning

confidence: 99%

Microbiota‐gut‐brain axis as a regulator of reward processes

García-Cabrerizo

Carbia

Riordan

et al. 2021

Journal of Neurochemistry

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The reward system is a set of neuronal structures responsible for the processing of a number of psychological components, such as 'wanting', 'liking' and associative learning (Berridge & Robinson, 2003).These three processes occur together, 'wanting' dominates the initial appetitive phase, 'liking' dominates the consummatory phase, and learning occurs through the reward-behavioural cycle (Berridge et al., 2016). Both phenomena are underpinned by different brain circuits and neurotransmitter systems. The 'wanting' component is largely controlled by the dopaminergic system, whereas the 'liking' component is thought to be more mediated by opioid and GABAergic systems (Berridge & Robinson, 2003). The neural circuitry constituting the anatomical and neurochemical substrate for reward and pleasure was described several decades ago by Olds and Milner, who, after implanting electrodes in certain areas of the central nervous system (CNS) and administering electrical microstimuli, demonstrated a pleasure response in the animals (Olds and Milner 1954).Following this, it was proposed that the monoaminergic activity could underlie the neurochemical basis of pleasure, with the monoaminergic system playing an important role in drug reinforcement

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“…Even in a living human being, there are up to several pounds of microbes. Some of them play important roles in our digestive system, immune system and even our mental health according to microbiome studies (Hayes et al, 2020). We all know that dental plaques, which are microbial biofilms, are unavoidable despite our daily brushing, flossing, and rinsing with an antiseptic mouthwash.…”

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confidence: 99%

Biocorrosion caused by microbial biofilms is ubiquitous around us

Dou

2020

Microbial Biotechnology

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Biocorrosion first surfaced in the scientific literature when Richard H. Gaines associated corrosion with bacterial activities in 1910. It is also known as microbiologically influenced corrosion (MIC). In general, it covers two scenarios. One is that microbes cause corrosion directly, which usually means microbes secrete corrosive metabolites or microbes harvest electrons from a metal for respiration to produce energy. In the second scenario, microbes are behind the initiation or acceleration of corrosion caused by a pre-existing corrosive agent such as water and CO 2 , by compromising the passive film (often a metal oxide film on a metal). MIC is caused by microbial biofilms. It is everywhere around us. This work dissects some notable examples with perspectives.

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Microbes and mental health: Can the microbiome help explain clinical heterogeneity in psychiatry?

Cited by 16 publications

References 132 publications

Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder

Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder

Microbiota‐gut‐brain axis as a regulator of reward processes

Biocorrosion caused by microbial biofilms is ubiquitous around us

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