Microbes and cancer geography: can we exploit recent lessons from the gut system to oral cancer context?

Garlet, Gustavo; Santos, Carlos

doi:10.1590/1678-77572014ed004

Cited by 1 publication

(1 citation statement)

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“…Interestingly, the susceptibility to local changes in the periodontium may not be directly related to oral biofilm composition or quantity, but rather, could be related to the subtle shifts on the systemic level, for instance, changes that occur in the gut's mucosal immune system. The gut and the oral cavity share similar features associated with a profuse microbial flora, and relatively common susceptibility for microbial‐driven chronic inflammation (Garlet & Santos, ). Hence, knowledge of whether the oral infection manifests systemic inflammation or vice versa has not been understood in detail.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic and inflammatory events in experimental periodontitis following systemic microbial challenge

Palioto

Finoti

Kinane

et al. 2019

J Clinic Periodontology

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Aim The purpose of this study was to determine inflammatory and epigenetic features following induction of oral and gut dysbiosis in experimental periodontitis in order to examine the interplay between oral and systemic infection. Materials and Methods Periodontitis was induced in 6‐ to 8‐week‐old C57BL/6 mice by (a) Ligature placement (Lig group) (oral challenge); (b) P. gingivalis gavage (Pg group) (systemic challenge); and (c) the combination of the two models oral and systemic challenge (Pg + Lig). The duration of the experiment was 60 days, and the animals were then sacrificed for analyses. Alveolar bone loss was assessed, and a multiplex immunoassay was performed. Maxillae and gut tissues were immunostained for DNMT3b (de novo methylation marker), B and T lymphocyte attenuator (BTLA) and IL‐18R1 (inflammation markers). Results Pg and Pg + Lig groups exhibited higher bone loss when compared to Sham. BAFF, VEGF, RANKL, RANTES and IP‐10 were significantly higher with Pg gavage. Likewise, DNMT3b was overexpressed in both gut and maxilla after the Pg administration. The same pattern was observed for BTLA and IL‐18R1 in gut tissues. Conclusions The systemic microbial challenge either alone or in combination with local challenge leads to distinct patterns of inflammatory and epigenetic features when compared to simply locally induced experimental periodontitis.

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Section: Introductionmentioning

confidence: 99%