Microbe-triggered arthropathies: reactive arthritis and beyond

Gupta, Ranjan; Misra, Ramnath

doi:10.1111/1756-185x.12920

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…There are different factors that stand behind the major shift in epidemiological data in ReA worldwide, among them are as follows: different diagnosis approach and clinical presentations, insufficient specific laboratory biomarkers, different geographical locations that predispose to multiple pathogens, different genetic backgrounds, different grades of infection, and microbiome changes observed recently [ 1 , 4 •, 5 ].…”

Section: Is the Epidemiology Of Rea Changing?mentioning

confidence: 99%

Reactive Arthritis: Update

Bentaleb

Abdelghani

Rostom

et al. 2020

Curr Clin Micro Rpt

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Purpose of Review The aim of this paper is to provide an overview about reactive arthritis, with an update regarding pathophysiology and therapeutic approach of the disease, outlining the clinical features and diagnostic approach, based on recent literature review. Recent Findings Reactive arthritis is considered to be part of the spectrum of the spondyloarthritis. Its epidemiology is changing worldwide due to several reasons, among them are as follows: different diagnosis approach and clinical presentations, different grades of infection, microbiome changes, etc. The understanding of pathophysiological models is challenging, but recent studies contribute to elucidate the major factors involved in the development of the disease. The management of ReA depends on the triggering agent and the phase of disease, whether it is acute or chronic. Summary The association between the microbiome changes and spondyloarthropathies (ReA) is becoming increasingly evident. The results regarding the biologic treatment on refectory ReA are promising.

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Section: Is the Epidemiology Of Rea Changing?mentioning

confidence: 99%

Reactive Arthritis: Update

Bentaleb

Abdelghani

Rostom

et al. 2020

Curr Clin Micro Rpt

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“…ReA usually occurs in people aged 18-40 years, with no significant difference between males and females. Because of the inconsistency of diagnostic criteria, differences in clinical severity, a lack of specific biomarkers, and inheritance factors, the epidemiology of ReA, with an incidence of 0.6-30 per 10.000, varies around the world [2][3][4][5]. Although ReA is a self-limiting disease, as many as 63% of patients with ReA develop chronic arthritis and they often have no significant response to treatment with traditional drugs [6].…”

Section: Introductionmentioning

confidence: 99%

Treatment of reactive arthritis with biological agents: a review

Zeng¹,

Luo²,

Zhang³

et al. 2020

Bioscience Reports

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The pathogenesis of reactive arthritis (ReA) has not been fully elucidated. In recent years, many researchers have confirmed that multiple cytokines are involved in the occurrence and development of ReA. Although ReA is self-limiting, it is still incurable for some patients who have no or a weak response to traditional drugs, such as non-steroidal anti-inflammatory agents, glucocorticoids and immunosuppressive agents. This is called refractory reactive arthritis. Currently, there is insufficient evidences for the treatment of refractory ReA with biological agents, though biological agents against cytokines have been developed over the past few years. This review summarizes the current development of clinical treatments of ReA with biological agents, which provides future investigations on refractory ReA with more evidence and references.

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Reactive arthritis: update 2018

et al. 2018

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At this time, reactive arthritis (ReA) is considered to be part of the spectrum of the spondyloarthritis, previously known as Reiter's syndrome, and refers to an infection induced systemic illness, characterized by a sterile synovitis occurring in a genetically predisposed individual, secondary to an infection localized in a distant organ/system, but also accompanied with multiple extra articular manifestations.

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Microbe-triggered arthropathies: reactive arthritis and beyond

Cited by 3 publications

References 19 publications

Reactive Arthritis: Update

Reactive Arthritis: Update

Treatment of reactive arthritis with biological agents: a review

Reactive arthritis: update 2018

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