Microbe Profile: Ruminococcus gnavus: the yin and yang of human gut symbionts

Juge, Nathalie

doi:10.1099/mic.0.001383

Cited by 5 publications

(3 citation statements)

References 11 publications

(27 reference statements)

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“…However, with the advancement of sequencing technology, studies have shown that species within the genus Ruminococcus belong to two bacterial families: Ruminococcaceae and Lachnospiraceae [ 29 ]. Some of these bacteria, such as Ruminococcus gnavus , have been shown to be associated with various intestinal and extraintestinal diseases and are increased in abundance in inflammatory bowel disease and metabolic diseases [ 30 , 31 , 32 ]. Unfortunately, limited by the accuracy of 16s analysis, the experiments were unable to explore the impact of Salmonella Typhimurium infection on duck intestinal microbiota at the species level.…”

Section: Discussionmentioning

confidence: 99%

Effects of Salmonella Typhimurium Infection on the Gut Microbiota of Cherry Valley Meat Ducks

Zheng,

Pan,

Hou

et al. 2024

Microorganisms

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Salmonella infection causes serious economic losses, threatens food safety, and is one of the most important diseases threatening meat duck farming. The gut microbiome is critical in providing resistance against colonization by exogenous microorganisms. Studying the relationship between Salmonella and gut microbiota can help us better understand the threat of the pathogenic mechanism of Salmonella and provide a more scientific theoretical basis for its prevention and treatment. This study uses Salmonella Typhimurium as the research object and Cherry Valley meat duck as the model with which to study the impact of Salmonella infection on ducks. In this field trial, 2 × 108 CFUs Salmonella Typhimurium were administered to 3-day-old ducks. After infection, duck viscera were collected to detect the colonization of Salmonella, and cecal contents were collected to analyze the changes in gut microbiota. The results show that Salmonella Typhimurium can colonize ducks three days after infection and alter the gut microbiota composition, mainly by increasing the abundance of Ruminococcaceae and Lachnospiraceae. In conclusion, Salmonella Typhimurium infection significantly alters the intestinal microbiota of ducks and poses a serious public health risk.

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Section: Discussionmentioning

confidence: 99%

Effects of Salmonella Typhimurium Infection on the Gut Microbiota of Cherry Valley Meat Ducks

Zheng,

Pan,

Hou

et al. 2024

Microorganisms

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“…Ruminococcus is a common bacterium in the feces of ruminants, mainly colonizing the jejunum and ileum of the intestinal lumen ( Guerra et al, 2022 ; Zhang et al, 2022 ), and is involved in the degradation of starch and other complex polysaccharides ( Rangarajan et al, 2022 ). Ruminococcus has also been well-documented as an inducer of active inflammation in animals ( Hall et al, 2017 ; Henke et al, 2021 ), and has been shown to play a role in the maintenance of homeostasis by acting as a key symbiotic component of the intestinal ecosystem ( La Reau and Suen, 2018 ; Crost et al, 2023 ; Juge, 2023 ). Paeniclostridium is a pathogenic bacterium ( DeCandia et al, 2023 ) that induces inflammation in the intestinal tract and in various tissues in animals ( Nyaoke et al, 2020 ; Gryaznova et al, 2021 ), via its ability to produce cytotoxic endotoxins ( Watts et al, 2019 ; Li et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of American ginseng (Panax quinquefolius L.) extract residue as a feed additive on production, health status, and gastrointestinal bacteria in sika deer (Cervus nippon)

Wu,

Zhao,

Zheng

et al. 2024

Front. Microbiol.

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American ginseng residue is an industrial by-product of ginseng saponin extraction, including polysaccharides and amino acids; however, it is often discarded into the natural environment, representing a waste of resources as well as an environmental issue. In this study, we examined the effects of adding American ginseng residue to the basal diet of sika deer. Twelve antler-bearing male sika deer were assigned randomly to groups fed a diet supplemented with 0% (CON), 1% (LGR), and 3% (HGR) American ginseng residue, respectively, (n = 4 per group) for 5 weeks. Supplementation with 3% American ginseng residue significantly increased antler production and feed utilization efficiency in antler-bearing sika deer (p < 0.05). There were no significant differences in serum biochemical indexes among the three groups, but serum immunoglobulin A and glutathione peroxidase levels were significantly increased in the LGR and HGR groups (p < 0.05). Supplementation with American ginseng residue affected rumen fermentation in sika deer, significantly increasing the rumen contents of acetic acid, propionic acid, and total volatile fatty acids, and decreasing rumen fluid pH (p < 0.05), but had no significant effect on microbial protein or ammoniacal nitrogen content. American ginseng residue also affected the rumen bacterial composition, with significant up-regulation of Bacteroidota abundance in the HGR group, significant increases in Fibrobacterota and Fibrobacter abundance in the LGR group, and a significant decrease in Oscillospiraceae_UCG-005. Supplementation with ginseng residue had no significant effect on volatile fatty acids in the feces of sika deer, but did affect the composition of fecal bacteria, with significant decreases in Desulfobacterota and Rikenellaceae_RC9_gut_group in the HGR group, and a significant increase in Ruminococcus in the LGR group (p < 0.05). In addition, the abundance of Paeniclostridium in the feces decreased linearly with increasing concentration of ginseng residue, with a significant difference among the groups (p < 0.05). This study comprehensively evaluated the effects of American ginseng residue as a potential feed additive on the production performance and gastrointestinal bacterial community in antler-bearing sika deer. The results indicated that ginseng residue was a suitable feed additive for improving production performance and health in sika deer.

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“…It belongs to the Firmicutes, it is also a member of the family Lachnospiraceae. An increasing number of enteric and extra-enteric diseases are associated with this bacterium [ 61 ]. Zhi-ying Song [ 4 ] and Yao Su [ 36 ] found that g-Ruminococcus was a characteristic biomarker for the normal pregnant women group and Ruminococcaceae_UCG014 was a characteristic biomarker for the GDM-only group, respectively.…”

Section: Relationship Between Intestinal Microbiome and Gdmmentioning

confidence: 99%

Association of gastrointestinal microbiome and obesity with gestational diabetes mellitus-an updated globally based review of the high-quality literatures

Li,

Wang,

et al. 2024

Nutr. Diabetes

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Objectives The purpose of this review is to investigate the relationship between gastrointestinal microbiome, obesity, and gestational diabetes mellitus (GDM) in an objective manner. Methods We conducted a thorough and comprehensive search of the English language literatures published in PubMed, Web of Science, and the Cochrane Library from the establishment of the library until 12 December 2023. Our search strategy included both keywords and free words searches, and we strictly applied inclusion and exclusion criteria. Meta-analyses and systematic reviews were prepared. Results Six high-quality literature sources were identified for meta-analysis. However, after detailed study and analysis, a certain degree of heterogeneity was found, and the credibility of the combined analysis results was limited. Therefore, descriptive analyses were conducted. The dysbiosis of intestinal microbiome, specifically the ratio of Firmicutes/Bacteroides, is a significant factor in the development of metabolic diseases such as obesity and gestational diabetes. Patients with intestinal dysbiosis and obesity are at a higher risk of developing GDM. Conclusions During pregnancy, gastrointestinal microbiome disorders and obesity may contribute to the development of GDM, with all three factors influencing each other. This finding could aid in the diagnosis and management of patients with GDM through further research on their gastrointestinal microbiome.

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Microbe Profile: Ruminococcus gnavus: the yin and yang of human gut symbionts

Abstract: Graphical abstract

Cited by 5 publications

References 11 publications

Effects of Salmonella Typhimurium Infection on the Gut Microbiota of Cherry Valley Meat Ducks

Effects of Salmonella Typhimurium Infection on the Gut Microbiota of Cherry Valley Meat Ducks

Beneficial effects of American ginseng (Panax quinquefolius L.) extract residue as a feed additive on production, health status, and gastrointestinal bacteria in sika deer (Cervus nippon)

Association of gastrointestinal microbiome and obesity with gestational diabetes mellitus-an updated globally based review of the high-quality literatures

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