Microarray Profiling of Circular RNA Identifies hsa_circ_0126991 as a Potential Risk Factor for Essential Hypertension

Liu, Liya; Gu, Tianlun; Bao, Xingjie; Zheng, Shuying; Zhao, Jinshun; Zhang, Lina

doi:10.1159/000500063

Cited by 17 publications

(7 citation statements)

References 31 publications

(31 reference statements)

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“…Additionally, five circRNAs, namely hsa_circ_0105130, hsa_circ_0109569, hsa_circ_0072659, hsa_circ_0079586, and hsa_circ_0064684, have been identified as being associated with essential hypertension [55]. Other circRNAs such as hsa_circ_0126991, hsa_circ_0014243, and hsa_circ_0037909 have also been recognized as potential biomarkers for essential hypertension [51,56,57]. Mechanistically, circRNAs can impact cardiovascular function by regulating the expression of transcription factors, microRNAs, and proteins, thereby influencing the development and progression of hypertension [58,59].…”

Section: Research Status Of Lncrnas and Circrnas In Cvd Hypertensionmentioning

confidence: 99%

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Jiang¹,

Hu²

2023

Clin. transl. rep.

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Cardiovascular and cerebrovascular diseases (CVD) encompass a range of conditions affecting the heart, brain, and blood vessels, including coronary heart disease, hypertension, and stroke. In recent years, there has been growing evidence highlighting the significant role of non-coding RNAs (ncRNAs) in the development and progression of cardiovascular diseases. Among the various types of ncRNAs, long-stranded non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have emerged as prominent players in cardiovascular research. Advancements in technology and in-depth research have revealed that ncRNAs and circRNAs exert regulatory effects on the biological functions of the cardiovascular system through various pathways. For instance, they can modulate the proliferation, migration, and apoptosis of vascular endothelial cells, as well as regulate cardiac muscle contraction and cardiomyocyte apoptosis. Additionally, ncRNAs and circRNAs can influence downstream targets and pathways involved in cardiovascular diseases. The exploration of ncRNAs and circRNAs in cardiovascular research has opened up new avenues for the diagnosis and treatment of CVDs. By understanding the intricate regulatory mechanisms mediated by these non-coding RNAs, researchers have gained valuable insights into the pathogenesis of cardiovascular diseases and identified potential therapeutic targets. Consequently, these studies have provided novel ideas and approaches for the diagnosis, prevention, and management of CVDs.

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Section: Research Status Of Lncrnas and Circrnas In Cvd Hypertensionmentioning

confidence: 99%

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Jiang¹,

Hu²

2023

Clin. transl. rep.

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“…Hypertension is a systemic disease, and its complex pathogenesis makes it difficult to elucidate the precise molecular mechanisms involved. Numerous studies have demonstrated that circRNAs are potential biomarkers and important modulators in hypertension ( Liu et al, 2017 ; Wu et al, 2017 ; Bao et al, 2018 ; Liu et al, 2019a ; Zheng et al, 2019 ; Lu et al, 2020 ; Yin et al, 2020 ; Zheng et al, 2020 ; He et al, 2021 ; Tao et al, 2021 ). CircRNA array analysis of blood samples obtained from patients with essential hypertension and healthy individuals showed that the expression of circRNAs was significantly different between these groups.…”

Section: Ev-circrnas Are Involved In As Risk Factorsmentioning

confidence: 99%

Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis

Wen

Nie

et al. 2022

Front. Cell Dev. Biol.

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Atherosclerosis (AS) is universally defined as chronic vascular inflammation induced by dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles as information transmitters regulate intracellular interactions and their important cargo circular RNAs are involved in the pathological process of AS. In this review, we summarize the current data to elucidate the emerging roles of extracellular vesicle-derived circular RNAs (EV-circRNAs) in AS and the mechanism by which EV-circRNAs affect the development of AS. Additionally, we discuss their vital role in the progression from risk factors to AS and highlight their great potential for use as diagnostic biomarkers of and novel therapeutic strategies for AS.

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“…We previously analyzed peripheral blood circRNAs between 5 diagnosed EH patients and 5 healthy controls using a microarray analysis and we found a total of 287 circRNAs were differentially expressed between the two groups including 209 up-regulated circRNAs and 78 down-regulated circRNAs. 13 For subsequent functional analysis to obtain the potential biomarkers for clinical application, the circRNAs were selected from the up-regulated exonic circRNAs (ecircRNAs) using the following filtering criteria: fold change >2.0 and P < .01. Then, hsa_circ_0093587 and hsa-circRNA9102-5 were included in this study.…”

Section: Candidate Circrnas and Their Target Mirnas Predictionmentioning

confidence: 99%

The up‐regulated hsa‐circRNA9102‐5 may be a risk factor for essential hypertension

Zheng

Sun

et al. 2020

Clinical Laboratory Analysis

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Background The present study was aimed to investigate the expression levels of circular RNAs (circRNAs) in the peripheral blood of essential hypertension (EH) patients and healthy controls (HC). On this basis, we tried to explain the possible role of circRNAs in the progression of EH and their potential as diagnostic biomarkers of EH. Methods First, we analyzed the differentially expressed circRNAs in peripheral blood obtained from the finished microarray analysis and selected four circRNAs under strict standards. Then, quantitative real‐time polymerase chain reaction (qRT‐PCR) was performed to measure the expression levels of the selected circRNAs in a total of 192 blood samples, consisting of 96 HC and 96 diagnosed EH patients. Bioinformatics prediction of the target microRNAs (miRNAs) was performed for differentially expressed circRNAs, and the circulating vascular‐related miRNAs were selected for qRT‐PCR analysis to determine their expression levels. Results Hsa‐circRNA9102‐5 (11.7 ± 1.06 vs 12.13 ± 1.11, P = .007) was up‐regulated in the patients group which was diagnosed with EH, as compared to the HC group, and was involved in the regulation of EH by sponging hsa‐miR‐150‐5p. The area under the ROC curve (AUC) of the model was 0.620, using hsa‐circRNA9102‐5 as an independent predictor. Furthermore, the AUC was increased to 0.728 when hsa‐circRNA9102‐5 was combined with hsa‐miR‐150‐5p and multiple other factors, as a combined predictor. Conclusions The present results suggested that hsa‐circRNA9102‐5 may have played a crucial role in the development of EH by sponging hsa‐miR‐150‐5p, which showed great potential as a novel target.

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Microarray Profiling of Circular RNA Identifies hsa_circ_0126991 as a Potential Risk Factor for Essential Hypertension

Cited by 17 publications

References 31 publications

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis

The up‐regulated hsa‐circRNA9102‐5 may be a risk factor for essential hypertension

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