Microarray patches enable the development of skin-targeted vaccines against COVID-19

Korkmaz, Emrullah; Balmert, Stephen C.; Sumpter, Tina L.; Carey, Cara Donahue; Erdö́s, G.; Falo, Louis D.

doi:10.1016/j.addr.2021.01.022

Cited by 52 publications

(44 citation statements)

References 400 publications

(383 reference statements)

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“… 42 In this sense the development of new strategies MAP-delivered for vaccines should be useful against emerging infectious diseases, including COVID-19. 43 …”

Section: Evidence From the Literaturementioning

confidence: 99%

Intradermal Vaccination: A Potential Tool in the Battle Against the COVID-19 Pandemic?

Migliore¹,

Gigliucci²,

Marzo³

et al. 2021

RMHP

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This narrative review is the final output of an initiative of the SIM (Italian Society of Mesotherapy). A narrative review of scientific literature on the efficacy of fractional intradermal vaccination in comparison with full doses has been conducted for the following pathogens: influenza virus, rabies virus, poliovirus (PV), hepatitis B virus (HBV), hepatitis A virus (HAV), diphtheria-tetanus-pertussis bacterias (DTP), human papillomavirus (HPV), Japanese encephalitis virus (JE), meningococcus, varicella zoster virus (VZV) and yellow fever virus. The findings suggest that the use of the intradermal route represents a valid strategy in terms of efficacy and efficiency for influenza, rabies and HBV vaccines. Some systematic reviews on influenza vaccines suggest the absence of a substantial difference between immunogenicity induced by a fractional ID dose of up to 20% and the IM dose in healthy adults, elderly, immunocompromised patients and children. Clinical studies of remaining vaccines against other pathogens (HAV, DTP bacterias, JE, meningococcal disease, VZV, and yellow fever virus) are scarce, but promising. In the context of a COVID-19 vaccine shortage, countries should investigate if a fractional dosing scheme may help to save doses and achieve herd immunity quickly. SIM urges the scientific community and health authorities to investigate the potentiality of fractionate intradermal administration in anti-COVID-19 vaccination.

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“… 42 In this sense the development of new strategies MAP-delivered for vaccines should be useful against emerging infectious diseases, including COVID-19. 43 …”

Section: Evidence From the Literaturementioning

confidence: 99%

Intradermal Vaccination: A Potential Tool in the Battle Against the COVID-19 Pandemic?

Migliore¹,

Gigliucci²,

Marzo³

et al. 2021

RMHP

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“…The skin is an attractive site for vaccination. Because of the Langerhans cells in the epidermis and the dendritic cells in the dermis, the skin would appear to be a better site for vaccination than muscle which lacks antigen-presenting cells [ 82 , 83 ]. This is supported by an animal experiment in which the results of microneedle array delivery of influenza vaccine to the skin were compared to intramuscular vaccination [ 84 ].…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa

Wertz

2021

IJMS

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PubMed searches reveal much literature regarding lipids in barrier function of skin and less literature on lipids in barrier function of the oral mucosa. In terrestrial mammals, birds, and reptiles, the skin’s permeability barrier is provided by ceramides, fatty acids, and cholesterol in the outermost layers of the epidermis, the stratum corneum. This layer consists of about 10–20 layers of cornified cells embedded in a lipid matrix. It effectively prevents loss of water and electrolytes from the underlying tissue, and it limits the penetration of potentially harmful substances from the environment. In the oral cavity, the regions of the gingiva and hard palate are covered by keratinized epithelia that much resemble the epidermis. The oral stratum corneum contains a lipid mixture similar to that in the epidermal stratum corneum but in lower amounts and is accordingly more permeable. The superficial regions of the nonkeratinized oral epithelia also provide a permeability barrier. These epithelial regions do contain ceramides, cholesterol, and free fatty acids, which may underlie barrier function. The oral epithelial permeability barriers primarily protect the underlying tissue by preventing the penetration of potentially toxic substances, including microbial products. Transdermal drug delivery, buccal absorption, and lipid-related disease are discussed.

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“…The ultimate success of MN-based drug delivery is founded on the critical parameters, which include their dimensions (shape, size, geometry), manufacturing method, and materials, as well as the type of therapeutics that could be delivered into the skin [ 10 ]. MNs are primarily investigated for the possibility of transdermal delivery of small therapeutic molecules [ 36 , 37 ], biomacromolecules [ 38 ], hormones [ 39 ], peptides [ 40 ], vaccines [ 41 , 42 ] (against SARS, MERS, COVID-19), and genes [ 43 ], as well as nanoparticles [ 44 ] in the treatment of pain [ 45 ] (e.g., migraine), and diseases such as diabetes [ 19 , 46 ], or hypertension [ 47 ]. It is important to mention that research is being done on the use of MNs in clinical drug monitoring [ 48 ].…”

Section: Microneedles: Characteristics Classification and Delivery Strategiesmentioning

confidence: 99%

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

et al. 2021

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Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs. This review aims to summarize various 3D printing technologies that can produce MNs from digital models in a single step, including a survey on their benefits and drawbacks. In addition, this paper highlights current research in the field of 3D printed MN-assisted transdermal drug delivery systems and analyzes parameters affecting the mechanical properties of 3D printed MNs. The current regulatory framework associated with 3D printed MNs as well as different methods for the analysis and evaluation of 3D printed MN properties are outlined.

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Microarray patches enable the development of skin-targeted vaccines against COVID-19

Cited by 52 publications

References 400 publications

Intradermal Vaccination: A Potential Tool in the Battle Against the COVID-19 Pandemic?

Intradermal Vaccination: A Potential Tool in the Battle Against the COVID-19 Pandemic?

Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

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