Microarray data reveal potential genes that regulate triple-negative breast cancer

Chi, Pan; Cong, Aihua; Ni, Qingtao

doi:10.1177/03000605221130188

Cited by 1 publication

(1 citation statement)

References 29 publications

(31 reference statements)

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“…Recently, researchers have focused on the pathogenic mechanisms underlying TNBC. For example, cyclin-dependent kinase 1 (CDK1) has been reported to be highly expressed in TNBC samples (5), whereas CDK14 can act as a tumor suppressor gene in TNBC (6). Furthermore, salt-inducible kinase 2 inhibitors may decrease DNA double-strand break repair in TNBC (7).…”

Section: Introductionmentioning

confidence: 99%

Radiation prevents tumor progression by inhibiting the miR‑93‑5p/EphA4/NF‑κB pathway in triple‑negative breast cancer

Chi

Shao

et al. 2023

Oncol Rep

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Breast cancer (BC) is the most common type of cancer in women. Triple-negative BC (TNBC) constitutes 10-15% of all BC cases and is associated with a poor prognosis. It has previously been reported that microRNA (miR)-93-5p is dysregulated in plasma exosomes from patients with BC and that miR-93-5p improves radiosensitivity in BC cells. The present study identified EphA4 as a potential target gene of miR-93-5p and investigated the pathway related to miR-93-5p in TNBC. Cell transfection and nude mouse experiments were performed to verify the role of the miR-93-5p/EphA4/NF-κB pathway. Moreover, miR-93-5p, EphA4 and NF-κB were detected in clinical patients. The results revealed that EphA4 and NF-κB were downregulated in the miR-93-5p overexpression group. By contrast, EphA4 and NF-κB expression levels were not significantly altered in the miR-93-5p overexpression + radiation group compared with those in the radiation group. Furthermore, overexpression of miR-93-5p with concomitant radiation therapy significantly decreased the growth of TNBC tumors in vivo. In conclusion, the present study revealed that miR-93-5p targeted EphA4 in TNBC through the NF-κB pathway. However, radiation therapy prevented tumor progression by inhibiting the miR-93-5p/EphA4/NF-κB pathway. Therefore, it would be interesting to elucidate the role of miR-93-5p in clinical research.

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Section: Introductionmentioning

confidence: 99%