Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study

Reams, Renee; Agrawal, Deepak; Davis, Melissa B.; Yoder, Sean; Odedina, Folakemi T.; Kumar, Nagi B.; Higginbotham, Joseph; Akinremi, Titilola O.; Suther, Sandra; Soliman, Karam F.A.

doi:10.1186/1750-9378-4-s1-s3

Cited by 53 publications

(54 citation statements)

References 7 publications

(6 reference statements)

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“…Similar findings to the Glasgow studies are apparent in studies aiming to determine why men of African American (AA) race are two to three times more likely to die from prostate cancer that European Americans (EA) (Horner et al 2009). Gene expression microarray studies of prostate cancer tissues from AA and EA men have consistently shown overexpression of gene sets involving inflammation pathways in AA samples (Powell et al 2013;Reams et al 2009;Wallace et al 2008). This includes differentially expressed gene clustering in pathways involved in immune response, interleukins, and cytokine signaling and overexpression of specific genes such as IL-6, IL-8, and IL-1β (Powell et al 2013;Reams et al 2009;Wallace et al 2008).…”

Section: Additional Innate Immune Cells In Prostate Cancermentioning

confidence: 98%

The Role of Inflammation in Prostate Cancer

Sfanos

Hempel

Marzo

2014

Advances in Experimental Medicine and Biology

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In the United States and in "Westernized" countries, the prevalence of both prostate cancer and prostate inflammation is very high, indicating that the two pathologies could be causally related. Indeed, chronic inflammation is now regarded as an "enabling" characteristic of human cancer. Prostate cancer incidence is thought to be mediated in part by genetics, but also by environmental exposures, including the same exposures that may contribute to the development of prostatic inflammation. As our understanding of the role of inflammation in cancer deepens, it is increasingly apparent that "inflammation" as a whole is a complex entity that does not always play a negative role in cancer etiology. In fact, inflammation can play potentially dichotomous (both pro and antitumorigenic) roles depending on the nature and the cellular makeup of the immune response. This chapter will focus on reviewing the current state of knowledge on the role of innate and adaptive immune cells within the prostate tumor microenvironment and their seemingly complex role in prostate cancer in preventing versus promoting initiation and progression of the disease.

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Section: Additional Innate Immune Cells In Prostate Cancermentioning

confidence: 98%

The Role of Inflammation in Prostate Cancer

Sfanos

Hempel

Marzo

2014

Advances in Experimental Medicine and Biology

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“…The most recent study by Reams et al compared gene expression profiling in tumors with a Gleason's score of 6 from AfricanAmerican males to prostate tumors in European-American males (23). This study also showed that the gene ontology terms prevalent in African-American male prostate tumor/ normal ratios included interleukins, progesterone signaling, chromatin-mediated maintenance and myeloid dendritic cell proliferation (23).…”

Section: Introductionmentioning

confidence: 82%

“…The study mostly detected differential expression of immune responsive genetic programs in African-American as compared to European-American patients that offer potentially important leads for understanding the disease (22). The most recent study by Reams et al compared gene expression profiling in tumors with a Gleason's score of 6 from AfricanAmerican males to prostate tumors in European-American males (23). This study also showed that the gene ontology terms prevalent in African-American male prostate tumor/ normal ratios included interleukins, progesterone signaling, chromatin-mediated maintenance and myeloid dendritic cell proliferation (23).…”

Section: Introductionmentioning

confidence: 99%

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Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African-American men

Dritschilo¹

2009

Int J Oncol

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Abstract. African-American (AA) men experience an increased risk of developing prostate cancers as well as increased mortality following treatment as compared to European-American (EA) men. The aim of our study was to identify biological factors with the potential to predispose AA men to prostate tumor progression and metastasis. To identify cancer-specific gene expression patterns in AA men, we established primary prostate cancer epithelial cells from 14 AA and 13 EA men. High-throughput microarrays were used to investigate differences in global gene expression comparing the two groups. Quantitative RT-PCR and immunohistochemistry validated mRNA and protein expression levels. RNAi knockdowns provided support for biological significance for the identified genes in prostate cancer cells. Son of sevenless homolog 1 (SOS1) was overexpressed in AA male-derived primary prostate cancer epithelial cells. Depletion of SOS1 in PC3 and DU145 prostate cancer cells resulted in decreased capacities for cell proliferation, migration and invasion, at least partially through inhibition of extracellular signal-regulated kinase 1 and 2. Tissue microarray analyses of SOS1 expression in prostate carcinomas correlated with Gleason's grades of tumors, consistent with a possible role in prostate cancer progression. Investigation of prostate cancer-derived epithelial cells has led to identification of SOS1 as a potential candidate biomarker and molecular therapeutic target in prostate cancer in AA men, consistent with the hypothesis that a biological basis exists for prostate cancer aggressiveness in AA men.

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“…Reams et al [33] observed that the transcription elongation factor A-like 7 (TCEAL 7) expression in PCa tumor and in non-tumor tissue was higher in EA compared to AA men. The TCEAL7 gene modulates transcription in a promoter context-dependent manner.…”

Section: Biological (Functional) Differences In Prostate Tumors Ofmentioning

confidence: 99%

Prostate cancer chemoprevention in men of African descent: current state of the art and opportunities for future research

Chornokur

Kumar

2013

Cancer Causes Control

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Prostate cancer is the most frequently diagnosed malignancy in men. However, African American / Black men are 60% more likely to be diagnosed with and 2.4 times more likely to die from prostate cancer, compared to Non-Hispanic White men. Despite the increased burden of this particular malignancy, no evidence-based recommendation regarding prostate cancer screening exists for the high risk population. Moreover, in addition to screening and detection, high-risk African American men may constitute a prime population for chemoprevention. Early detection and chemoprevention may thus represent an integral part of prostate cancer control in this population. Importantly, recent research have elucidated biological differences in the prostate tumors of African American compared to European American men,. The latter may enable a more favorable response in African American men to specific chemopreventive agents that target relevant signal transduction pathways. Based on this evolving evidence, the aims of this review are three-fold. First, we aim to summarize the biological differences that were reported in the prostate tumors of African American and European American men. Second, we will review the single and multi target chemopreventive agents placing specific emphasis on targeting the pathways implicated in prostate carcinogenesis. And lastly, we will discuss the most promising multi-target nutraceutical chemopreventive compounds. Our review underscores the promise of chemoprevention in prostate cancer control, as well as provides justification for further growth and investment in this filed to ultimately reduce prostate cancer morbidity and mortality in this high risk population of African American men.

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Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study

Cited by 53 publications

References 7 publications

The Role of Inflammation in Prostate Cancer

The Role of Inflammation in Prostate Cancer

Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African-American men

Prostate cancer chemoprevention in men of African descent: current state of the art and opportunities for future research

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