Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system

Genter, Mary Beth; Veldhoven, Paul P. Van; Jegga, Anil G.; Sakthivel, Bhuvana; Kong, Sue; Stanley, Kristin; Witte, David P.; Ebert, Catherine L.; Aronow, Bruce J.

doi:10.1152/physiolgenomics.00117.2003

Cited by 53 publications

(46 citation statements)

References 83 publications

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“…Downregulation of SPL in neoplastic intestinal tissues, combined implicated SPL and its impact on S1P metabolism and calcium homeostasis as potentially playing a role in Darier's disease, which is caused by a defect in keratinocyte adhesion and differentiation ( 64 ). Our fi nding of SPL expression in discrete glomeruli of the olfactory bulb and embryonic olfactory mucosa is consistent with reports demonstrating Sgpl1 expression and activity in this location by other methods ( 66,67 ). Combined with the fi nding of high SPL expression in the preputial gland, which is responsible for synthesis of pheromones, these fi ndings suggest that SPL may play a role in olfactory organ function and the biosynthesis, metabolism, and/or detection of pheromones.…”

Section: Expression Of Spl During Murine Developmentsupporting

confidence: 88%

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues

Borowsky

Bandhuvula²,

Kumar³

et al. 2012

Journal of Lipid Research

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This article is available online at http://www.jlr.org Sphingosine-1-phosphate (S1P) is the fi nal metabolic product of sphingolipid degradation. It circulates in the blood and lymph bound to lipoproteins and functions as a ligand for a family of fi ve differentially expressed G proteincoupled receptors, the S1P receptors (S1PRs) ( 1, 2 ). Acting through these receptors and the downstream signaling events mediated by them, S1P infl uences cell migration, survival, and stress responses ( 3 ). S1PR signaling is critical for development, as demonstrated by the embryonic lethal phenotype of S1PR1 knockout mice, due to severe hemorrhage associated with impaired vascular maturation ( 4 ). S1PR2 knockout mice are deaf due to defects in the stria vascularis ( 5 ). Additional studies have demonstrated the importance of S1P transport and signaling in cardiac and brain development, reproduction, and embryonic stem cell survival ( 6-17 ). S1P acts through its cognate receptors to control T, B, natural killer, and hematopoietic stem cell traffi cking as these cells emerge from bone marrow and thymus and transit peripheral lymphoid organs ( 18,19 ). S1P signaling contributes to the regulation and constitutive activation of key transcription factors that play a central role in infl ammation and cancer, including nuclear factor-B and STAT3 ( 20,21 ). S1P is also a mediator of cardioprotection in response to ischemia and can reduce developmental cell death as well as apoptosis, tissue injury, and infertility in response to ionizing radiation ( 22-24 ). Although many effects of S1P signaling are mediated through activation of its receptors, some of its actions, including activation of nuclear factor-B signaling and regulation of histone deacetylases, appear to be mediated through the receptor-independent, intracellular functions of S1P ( 21,25 ). S1P is generated via phosphorylation of the sphingoid base sphingosine by sphingosine kinases SphK1 and SphK2Abstract Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, infl ammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme responsible for S1P degradation. SPL augments apoptosis and is down-regulated in cancer. SPL generates a S1P chemical gradient that promotes lymphocyte traffi cking and as such is being targeted to treat autoimmune diseases. Despite growing interest in SPL as a disease marker, antioncogene, and pharmacological target, no comprehensive characterization of SPL expression in mammalian tissues has been reported. We investigated SPL expression in developing and adult mouse tissues by generating and characterizing a ␤ -galactosidase-SPL reporter mouse combined with immunohistochemistry, immunoblotting, and enzyme assays. SPL was expressed in thymic and splenic stromal cells, splenocytes, Peyer's Patches, colonic lymphoid aggregates, circulating T and B lymphocytes, granulocytes, and monocytes, with lowest expression in thymocytes. SPL was highly expressed within the CNS, including arachnoid lining cells, spinal cord, ch...

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Section: Expression Of Spl During Murine Developmentsupporting

confidence: 88%

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues

Borowsky

Bandhuvula²,

Kumar³

et al. 2012

Journal of Lipid Research

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“…BPIFA1, or SPLUNC1 (previously known as PLUNC, LUNX, SPURT, and YY1), is one of the most widely studied PLUNC proteins. BPIFA1 was originally identified in mice in a study seeking genetic contributions to palatal malformations, and it is frequently identified in genomic and proteomic studies of healthy and diseased lung tissue and respiratory secretions (11)(12)(13)(14)(15)(16).…”

Section: The Bpif and Plunc Protein Familiesmentioning

confidence: 99%

“…BPIFA1 mRNA expression is absent in peripheral lung tissue from healthy human or mouse lungs (9,11,32). BPIFA1 is not expressed outside of the rodent respiratory tract, with the exception of limited mRNA expression in rat heart, mouse thymus, and olfactory mucosa (15,(33)(34)(35)(36). In humans, limited BPIFA1 expression outside of the respiratory tract has been reported in the kidney and colon (37).…”

Section: Expression and Distributionmentioning

confidence: 99%

Bactericidal/Permeability-Increasing Protein Fold–Containing Family Member A1 in Airway Host Protection and Respiratory Disease

Britto

Cohn

2015

Am J Respir Cell Mol Biol

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“…This approach leads to networks in which connections may represent co-regulation of gene sets by the same transcription factor(s), or regulation of target genes by other genes that encode transcription factor proteins. In either case, connected genes are often elements of the same biological pathway (Genter et al, 2003;Zhang et al, 2004;Wolfe et al, 2005;Ulitsky and Shamir, 2007), and such genes may participate in similar biological processes (but see Allocco et al, 2004 andYeung et al, 2004a). An interesting property of transcription networks, indeed most biological networks, is a "scale-free" topology, where few hub genes are highly connected to many other genes, with numerous weakly-connected genes located peripherally to highly-connected hubs (Guelzim et al, 2002;Siegal et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Genes regulated by caloric restriction have unique roles within transcriptional networks

Swindell

2008

Mechanisms of Ageing and Development

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Caloric restriction (CR) has received much interest as an intervention that delays age-related disease and increases lifespan. Whole-genome microarrays have been used to identify specific genes underlying these effects, and in mice, this has led to the identification of genes with expression responses to CR that are shared across multiple tissue types. Such CR-regulated genes represent strong candidates for future investigation, but have been understood only as a list, without regard to their broader role within transcriptional networks. In this study, co-expression and network properties of CR-regulated genes were investigated using data generated by more than 600 Affymetrix microarrays. This analysis identified groups of co-expressed genes and regulatory factors associated with the mammalian CR response, and uncovered surprising network properties of CR-regulated genes. Genes downregulated by CR were highly connected and located in dense network regions. In contrast, CR-upregulated genes were weakly connected and positioned in sparse network regions. Some network properties were mirrored by CR-regulated genes from invertebrate models, suggesting an evolutionary basis for the observed patterns. These findings contribute to a systems-level picture of how CR influences transcription within mammalian cells, and point towards a comprehensive understanding of CR in terms of its influence on biological networks.

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Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system

Abstract: . Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system.

Cited by 53 publications

References 83 publications

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues

Bactericidal/Permeability-Increasing Protein Fold–Containing Family Member A1 in Airway Host Protection and Respiratory Disease

Genes regulated by caloric restriction have unique roles within transcriptional networks

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