Microarray analysis of the genes associated with osteitis in chronic rhinosinusitis

Günel, Ceren; Bleier, Benjamin S.; Bozkurt, Gökay; Eliyatkın, Nüket

doi:10.1002/lary.26414

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…Additionally, due to technical considerations, we restricted our analysis to the diseased mucosal tissue as opposed to the bone itself. However, as previously noted, multiple previous studies have established that the mucosa is an important regulator of underlying bone homeostasis . Furthermore, the results of the whole transcriptome were not reported in the present study, and so the whole profiles of other significantly altered transcripts in CRSwNP were not accounted for.…”

Section: Discussioncontrasting

confidence: 54%

“…However, as previously noted, multiple previous studies have established that the mucosa is an important regulator of underlying bone homeostasis. 34,45 Furthermore, the results of the whole transcriptome were not reported in the present study, and so the whole profiles of other significantly altered transcripts in CRSwNP were not accounted for. Finally, the tissue biopsies for mRNA evaluation contained several different cell types, which might have up-and downregulated transcripts in opposite directions, which may have masked some additional significant findings.…”

Section: Discussionmentioning

confidence: 68%

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Osteitis is associated with dysregulated pro‐osteoblastic activity in patients with nasal polyps

Nocera

Müller

et al. 2018

The Laryngoscope

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Objectives/Hypothesis The overlying inflammatory mucosa plays a crucial role in the initiation of osteitis; however, the molecular mechanism is unclear. The objective of this study was to explore the bone morphogenetic protein (BMP) pathway and to correlate the expression of key signaling molecules with the degree of osteitis in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Study Design Prospective experimental analysis. Methods This was an institutional review board–approved study in which mucosal samples were obtained from sites of osteitis in CRSwNP and compared to nonosteitic healthy controls (n = 10/group). Protein expression of key BMP pathway was quantified by aptamer‐based protein array and confirmed by a set of selected mRNA analyses. Degree of osteitis was assessed using both Kennedy Osteitis Score and Global Osteitis Score (GOS). Results Pro‐osteoblastic expression of BMP7 (fold change [FC] = −1.18, P = .017) and BMP9 (FC = −1.32, P = .023), their receptors, BMP receptor type‐1A (BMPR1A) (FC = −2.56, P = .005) and BMP receptor type‐2 (FC = −1.28, P = .022), and two enhancers of BMP signaling pathway, the repulsive guidance molecule domain family member B (FC = −1.13, P = .008) and the chordin‐like protein 1 (FC = −1.18, P = .027), were all significantly downregulated in CRSwNP. Conversely, the pro‐osteoclastic factor, tartrate‐resistant acid phosphatase type 5 (ACP5) (FC = 2.36, P = .001), was significantly increased in CRSwNP. GOS was inversely correlated with levels of BMP7 (r = −0.684, P = .005) and BMPR1A (r = −0.864, P = .005) and positively correlated with levels of ACP5 (r = 0.815, P = .004). The FCs among the proteins studied significantly and positively correlated with the FCs of their mRNA expression (r = 0.908, P = .002). Conclusions Downregulated pro‐osteoblastic mucosal BMP signaling is strongly and significantly associated with increased osteitis in CRSwNP. Level of Evidence NA Laryngoscope, 129:E102–E109, 2019

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 68%

Osteitis is associated with dysregulated pro‐osteoblastic activity in patients with nasal polyps

Nocera

Müller

et al. 2018

The Laryngoscope

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“…The bone morphogenic protein (BMP) family is 1 signaling pathway that has been investigated. Growth differentiation factor 5 (GDF5), a member of the BMP family, was found to be upregulated in osteitic bone 671 . Additionally, Wu et al 672 identified that downregulation of pro‐osteoblastic BMP signaling correlates to increased neo‐osteogenesis in CRSwNP patients.…”

Section: Chronic Rhinosinusitis Without Nasal Polyps (Crssnp)mentioning

confidence: 99%

International consensus statement on allergy and rhinology: rhinosinusitis 2021

Orlandi

Kingdom

Smith

et al. 2021

Int Forum Allergy Rhinol

422

475

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I. Executive Summary Background The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

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“…37 Complete sinus surgery before aspirin desensitization can effectively reduce sinus symptoms and need for revision surgery. 38 Furthermore, long-term inflammation and osteitis ( Fig 5) in patients with CRS 39,40 can have a significant effect on the ability of the sinuses to return to a quiescent functional baseline status. Additional trials together with a better understanding of the molecular mechanisms of CRS will advance our diagnostic criteria on when to intervene surgically for CRS.…”

Section: Indications For Surgical Interventionmentioning

confidence: 99%

Evolution in the surgical management of chronic rhinosinusitis: Current indications and pitfalls

Kohanski

Toskala

Kennedy

2018

Journal of Allergy and Clinical Immunology

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Chronic rhinosinusitis (CRS) consists of a range of inflammatory conditions in the sinuses that can result in clinical symptoms. The underlying pathophysiology and its relationship to lower airway disease are complex. Current definitions of CRS can serve more as an indication for potential surgical intervention rather than a marker of disease state. CRS can be asymptomatic and may require medical management to avoid disease progression and minimize the risk of lower airway disease. Endoscopic surgery has undergone a significant evolution and refinement, but the most common surgical complication remains persistent inflammation and disease recurrence. It is important to recognize that surgery alone rarely cures CRS and patients require long-term medical therapy for continued asymptomatic inflammation. Careful postoperative care and endoscopic follow-up to ensure resolution of inflammation are key to ensuring optimal surgical outcomes and reduce the risk of revision surgery. Future work on CRS endotypes will allow discovery of new therapies to treat CRS, as well as refine indications for medical or surgical intervention and postoperative care.

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Microarray analysis of the genes associated with osteitis in chronic rhinosinusitis

Abstract: NA Laryngoscope, 127:E85-E90, 2017.

Cited by 9 publications

References 19 publications

Osteitis is associated with dysregulated pro‐osteoblastic activity in patients with nasal polyps

Osteitis is associated with dysregulated pro‐osteoblastic activity in patients with nasal polyps

International consensus statement on allergy and rhinology: rhinosinusitis 2021

Evolution in the surgical management of chronic rhinosinusitis: Current indications and pitfalls

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