Microarray analysis of lncRNAs and mRNAs in spinal cord contusion rats with iPSC-derived A2B5+ oligodendrocyte precursor cells transplantation

Yuan, Hao; Chen, Li; Zhang, Lan-Chun; Shi, Lan-Lan; Han, Xue-Fei; Liu, Su; Xiong, Liu-Lin; Wang, Ting-Hua

doi:10.1016/j.heliyon.2023.e22808

Cited by 1 publication

(1 citation statement)

References 49 publications

(54 reference statements)

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“…Combined with the findings, it can be demonstrated that HACC hydrogel scaffolds also have the advantage of promoting GDNF secretion from stem cells. In addition, previous studies have also shown that GDNF significantly improved the viability of bone marrow mesenchymal stem cells (BMSCs) during induction and promoted the proliferation of BMSCs ( Yuan et al, 2024 ). The results of the study showed that after HACC/BMSCs were administered, the expression levels of NF200 and glial fibrillary acidic protein (GFAP) were significantly higher in the area of the spinal cord lesion.…”

Section: Combined Application Of Biomaterialsmentioning

confidence: 99%

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Gao,

Wang,

et al. 2024

Front. Cell. Neurosci.

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Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, and autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, and chronic. In each period there are different alterations in the cells, inflammatory factors, and signaling pathways within the spinal cord. Many biomaterials have been investigated in the treatment of SCI, including hydrogels and fiber scaffolds, and some progress has been made in the treatment of SCI using multiple materials. However, there are limitations when using individual biomaterials in SCI treatment, and these limitations can be significantly improved by combining treatments with stem cells. In order to better understand SCI and to investigate new strategies for its treatment, several combination therapies that include materials combined with cells, drugs, cytokines, etc. are summarized in the current review.

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Section: Combined Application Of Biomaterialsmentioning

confidence: 99%